Journal article
Precision Genomic Medicine in Cystic Fibrosis
Clinical and translational science, Vol.8(5), pp.606-610
10/2015
DOI: 10.1111/cts.12292
PMCID: PMC4626267
PMID: 26073768
Abstract
The successful application of precision genomic medicine requires an understanding of how a person's genome can influence his or her disease phenotype and how medical therapies can provide personalized therapy to one's genotype. In this review, we highlight advances in precision genomic medicine in cystic fibrosis (CF), a classic autosomal recessive genetic disorder. We discuss genotype-phenotype correlations in CF, genetic and environmental modifiers of disease, and pharmacogenetic therapies that target specific genetic mutations thereby addressing the primary defect of cystic fibrosis.
Details
- Title: Subtitle
- Precision Genomic Medicine in Cystic Fibrosis
- Creators
- Eugene H Chang - Department of Otolaryngology-Head and Neck Surgery, The University of Arizona College of Medicine, Tucson, Arizona, USAJoseph Zabner - Department of Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Clinical and translational science, Vol.8(5), pp.606-610
- DOI
- 10.1111/cts.12292
- PMID
- 26073768
- PMCID
- PMC4626267
- ISSN
- 1752-8054
- eISSN
- 1752-8062
- Grant note
- 1K08DE021413-01A1 / NIDCR NIH HHS P30 DK054759 / NIDDK NIH HHS K08 DE021413 / NIDCR NIH HHS
- Language
- English
- Date published
- 10/2015
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094211402771
Metrics
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