Journal article
Precision Medicine in Pancreatic Disease—Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
Pancreas, Vol.48(10), pp.1250-1258
01/01/2019
DOI: 10.1097/MPA.0000000000001412
PMCID: PMC7282491
PMID: 31688587
Abstract
A workshop on research gaps and opportunities for Precision Medicine in Pancreatic Disease was sponsored by the National Institute of Diabetes and Digestive Kidney Diseases on July 24, 2019, in Pittsburgh. The workshop included an overview lecture on precision medicine in cancer and 4 sessions: (1) general considerations for the application of bioinformatics and artificial intelligence; (2) omics, the combination of risk factors and biomarkers; (3) precision imaging; and (4) gaps, barriers, and needs to move from precision to personalized medicine for pancreatic disease. Current precision medicine approaches and tools were reviewed, and participants identified knowledge gaps and research needs that hinder bringing precision medicine to pancreatic diseases. Most critical were (
a
) multicenter efforts to collect large-scale patient data sets from multiple data streams in the context of environmental and social factors; (
b
) new information systems that can collect, annotate, and quantify data to inform disease mechanisms; (
c
) novel prospective clinical trial designs to test and improve therapies; and (
d
) a framework for measuring and assessing the value of proposed approaches to the health care system. With these advances, precision medicine can identify patients early in the course of their pancreatic disease and prevent progression to chronic or fatal illness.
Details
- Title: Subtitle
- Precision Medicine in Pancreatic Disease—Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
- Creators
- Mark E. Lowe - Washington University in St. LouisDana K. Andersen - National Institute of Diabetes and Digestive and Kidney DiseasesRichard M. Caprioli - Vanderbilt UniversityJyoti Choudhary - Institute of Cancer ResearchZobeida Cruz-Monserrate - The Ohio State University Wexner Medical CenterAnil K. Dasyam - University of PittsburghChristopher E. Forsmark - Department of Pediatrics, School of Medicine, Washington University, St Louis, MO The Division of Digestive Diseases and Nutrition, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD Department of Biochemistry, Vanderbilt University, Nashville, TN Department of Chemistry, Vanderbilt University, Nashville, TN Department of Pharmacology and Medicine, Vanderbilt University, Nashville, TN Institute of Cancer Research, London, United Kingdom Division of Gastroenterology, Hepatology, and Nutrition, Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH Department of Radiology, University of Pittsburgh, Pittsburgh, PA The Division of Gastroenterology, Hepatology and Nutrition, University of Florida, Gainesville, FL Department of Internal Medicine, Yale University, New Haven, CT Department of Cell Biology, School of Medicine, Yale University, New Haven, CT VA Connecticut Healthcare System, West Haven, CT Knight Cancer Institute, Oregon Health and Science University, Portland, OR Ariel Precision Medicine, Pittsburgh, PA Department of Biomedical Engineering, University of Virginia, Charlottesville, VA Department of Medicine, Columbia University, New York, NY Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY Department of Biomedical Data Science, Stanford University, Stanford, CA Department of Radiology, Stanford University, Stanford, CA Institute for Systems Biology, Seattle, WA Deep Learning for Medical Imaging, NVIDIA Corporation, Bethesda, MD Proteomics Center, Boston Children’s Hospital, Department of Pathology, Harvard Medical School, Boston, MA Department of Pathology and Immunology, School of Medicine, Washington University, St Louis, MO Department of Radiology and Imaging Sciences, School of Medicine, Indiana University, Indianapolis, IN Division of Gastroenterology, Stead Family Department of Pediatrics, The University of Iowa, Iowa City, IA Computational Medicine and Systems Medicine, Department of Digestion, Metabolism and Reproduction, Imperial College, London, United Kingdom Department of Medicine, University of Pittsburgh, Pittsburgh, PA Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA Department of Physiology and Genetics, University of Pittsburgh, Pittsburgh, PA Division of Gastroenterology and Hepatology, Stanford University, Stanford, CAFred S. Gorelick - West Haven VA Medical CenterJoe W. Gray - Oregon Health & Science UniversityMark Haupt - Ariel Precision Medicine, Pittsburgh, PA.Kimberly A. Kelly - University of VirginiaKenneth P. Olive - Columbia UniversitySylvia K. Plevritis - Stanford UniversityNoa Rappaport - Institute for Systems BiologyHolger R. Roth - NvidiaHanno Steen - Boston Children's HospitalS. Joshua Swamidass - Washington University in St. LouisTemel Tirkes - Indiana University – Purdue University IndianapolisAliye Uc - University of IowaKirill Veselkov - Imperial College LondonDavid C. Whitcomb - University of PittsburghAida Habtezion - Stanford University
- Resource Type
- Journal article
- Publication Details
- Pancreas, Vol.48(10), pp.1250-1258
- DOI
- 10.1097/MPA.0000000000001412
- PMID
- 31688587
- PMCID
- PMC7282491
- NLM abbreviation
- Pancreas
- ISSN
- 0885-3177
- eISSN
- 1536-4828
- Language
- English
- Date published
- 01/01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Radiation Oncology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
- Record Identifier
- 9984313074902771
Metrics
13 Record Views