Journal article
Precision in Cardiovascular Care Using Targeted Neonatal Echocardiography in Lethal Neonatal Disseminated Herpes Infection A Case Series
The Pediatric infectious disease journal, Vol.40(6), pp.566-570
06/01/2021
DOI: 10.1097/INF.0000000000003071
PMID: 33470772
Abstract
Neonates with disseminated neonatal herpes simplex virus infection often present with cardiorespiratory failure. The pathophysiological contributors to the disease phenotype, biologic mechanisms underlying the hemodynamic instability and optimal approach to cardiovascular treatment have not been well described. We describe clinical and echocardiography features of cardiovascular dysfunction, in a case series of neonates with disseminated herpes simplex virus, and response to physiology-based hemodynamic management. The biologic phenotype includes low systemic vascular resistance state, hypovolemia secondary to third space losses, myocardial dysfunction and pulmonary hypertension. Early targeted neonatal echocardiography provided hemodynamic insights on blood flow, shunt characterization, vascular resistance and cardiac function, that were difficult to gauge clinically (eg, differentiating parenchymal from pulmonary vascular disease) thereby positively impacted clinical care. All patients were stabilized hemodynamically without utilizing extracorporeal membrane oxygenation, although all patients died of multiorgan failure.
Details
- Title: Subtitle
- Precision in Cardiovascular Care Using Targeted Neonatal Echocardiography in Lethal Neonatal Disseminated Herpes Infection A Case Series
- Creators
- Soume Bhattacharya - Western UniversityPatrick J. McNamara - University of TorontoRegan E. Giesinger - University of Toronto
- Resource Type
- Journal article
- Publication Details
- The Pediatric infectious disease journal, Vol.40(6), pp.566-570
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/INF.0000000000003071
- PMID
- 33470772
- ISSN
- 0891-3668
- eISSN
- 1532-0987
- Number of pages
- 5
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984354118402771
Metrics
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