Journal article
Precision medicine in immune checkpoint blockade therapy for non-small cell lung cancer
Clinical and translational medicine, Vol.6(1), pp.1-4
12/2017
DOI: 10.1186/s40169-017-0136-7
PMCID: PMC5250626
PMID: 28108884
Abstract
Immune checkpoint blockade therapy by targeting the programmed death protein 1/programmed death ligand 1 (PD-L1) axis using antibodies has yielded promising clinical responses in patients with non-small cell lung cancer (NSCLC). However, owing to the dynamic expression of PD-L1, degree of mutational/neoantigen load, intratumoral heterogeneity, infiltrated immune cells of tumor microenvironment of NSCLC, the response rates to these agents are limited, despite several companion diagnostic assays by detecting PD-L1 in tumor cells have been introduced into clinical practice. Therefore, in this era of precision medicine, there is an urgent need for predictive biomarkers to identify NSCLC patients likely to benefit from this novel therapy.
Details
- Title: Subtitle
- Precision medicine in immune checkpoint blockade therapy for non-small cell lung cancer
- Creators
- Xiaoming Liu - Yinchuan, 750004 Ningxia ChinaWilliam C Cho - Kowloon, Hong Kong
- Resource Type
- Journal article
- Publication Details
- Clinical and translational medicine, Vol.6(1), pp.1-4
- DOI
- 10.1186/s40169-017-0136-7
- PMID
- 28108884
- PMCID
- PMC5250626
- NLM abbreviation
- Clin Transl Med
- ISSN
- 2001-1326
- eISSN
- 2001-1326
- Publisher
- Springer Berlin Heidelberg; Berlin/Heidelberg
- Language
- English
- Date published
- 12/2017
- Academic Unit
- Anatomy and Cell Biology
- Record Identifier
- 9984025304602771
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