Journal article
Preclinical Experience of the Mayo Spheroid Reservoir Bioartificial Liver (SRBAL) in Management of Acute Liver Failure
Livers, Vol.2(4), pp.387-399
12/01/2022
DOI: 10.3390/livers2040029
Abstract
The Spheroid Reservoir Bioartificial Liver (SRBAL) is an innovative treatment option for acute liver failure (ALF). This extracorporeal support device, which provides detoxification and other liver functions using high-density culture of porcine hepatocyte spheroids, has been reported in three randomized large animal studies. A meta-analysis of these three preclinical studies was performed to establish efficacy of SRBAL treatment in terms of survival benefit and neuroprotective effect. The studies included two hepatotoxic drug models of ALF (D-galactosamine, alpha-amanitin/lipopolysaccharide) or a liver resection model (85% hepatectomy) in pigs or monkeys. The SRBAL treatment was started in three different settings starting at 12 h, 24 h or 48 h after induction of ALF; comparisons were made with two similar control groups in each model. SRBAL therapy was associated with significant survival and neuroprotective benefits in all three animal models of ALF. The benefits of therapy were dose dependent with the most effective configuration of SRBAL being continuous treatment of 24 h duration and dose of 200 g of porcine hepatic spheroids. Future clinical testing of SRBAL in patients with ALF appears warranted.
Details
- Title: Subtitle
- Preclinical Experience of the Mayo Spheroid Reservoir Bioartificial Liver (SRBAL) in Management of Acute Liver Failure
- Creators
- Philipp Felgendreff - Mayo Clinic in ArizonaMohammad Tharwat - Zagazig UniversitySeyed M. Hosseiniasl - Mayo Clinic in ArizonaBruce P. Amiot - Mayo Clinic in ArizonaAnna Minshew - Mayo Clinic in ArizonaAnan A. Abu Rmilah - Mayo Clinic in ArizonaXiaoye Sun - Mayo Clinic in ArizonaDustin Duffy - Mayo Clinic in ArizonaWalter K. Kremers - Mayo Clinic in ArizonaScott L. Nyberg - Mayo Clinic
- Resource Type
- Journal article
- Publication Details
- Livers, Vol.2(4), pp.387-399
- Publisher
- Mdpi
- DOI
- 10.3390/livers2040029
- ISSN
- 2673-4389
- eISSN
- 2673-4389
- Number of pages
- 13
- Grant note
- JS 3903 / Egyptian Cultural and Educational Bureau; Egyptian Cultural & Educational Bureau P30DK084567; R01DK106667 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA FE 2089/1-1 / Deutsche Forschungsgesellschaft (DFG); German Research Foundation (DFG) Mayo Foundation
- Language
- English
- Date published
- 12/01/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984845250602771
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