Journal article
Preclinical Models of Neuroendocrine Neoplasia
Cancers, Vol.14(22), p.5646
11/17/2022
DOI: 10.3390/cancers14225646
PMCID: PMC9688518
PMID: 36428741
Abstract
Neuroendocrine neoplasia (NENs) are a complex and heterogeneous group of cancers that can arise from neuroendocrine tissues throughout the body and differentiate them from other tumors. Their low incidence and high diversity make many of them orphan conditions characterized by a low incidence and few dedicated clinical trials. Study of the molecular and genetic nature of these diseases is limited in comparison to more common cancers and more dependent on preclinical models, including both in vitro models (such as cell lines and 3D models) and in vivo models (such as patient derived xenografts (PDXs) and genetically-engineered mouse models (GEMMs)). While preclinical models do not fully recapitulate the nature of these cancers in patients, they are useful tools in investigation of the basic biology and early-stage investigation for evaluation of treatments for these cancers. We review available preclinical models for each type of NEN and discuss their history as well as their current use and translation.
Details
- Title: Subtitle
- Preclinical Models of Neuroendocrine Neoplasia
- Creators
- Andrew J. H. Sedlack - National Institute of Biomedical Imaging and BioengineeringKimia Saleh-Anaraki - National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH), Bethesda, MD 20892, USA Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA National Cancer Institute, NIH, Bethesda, MD 20892, USA Department of Surgery, University of Iowa, Iowa City, IA 52242, USA Oxford Center for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242, USASuresh Kumar - National Cancer InstitutePo Hien Ear - University of IowaKate E. Lines - National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH), Bethesda, MD 20892, USA Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA National Cancer Institute, NIH, Bethesda, MD 20892, USA Department of Surgery, University of Iowa, Iowa City, IA 52242, USA Oxford Center for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242, USANitin Roper - National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH), Bethesda, MD 20892, USA Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA National Cancer Institute, NIH, Bethesda, MD 20892, USA Department of Surgery, University of Iowa, Iowa City, IA 52242, USA Oxford Center for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242, USAKarel Pacak - University of IowaEmily Bergsland - National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH), Bethesda, MD 20892, USA Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA National Cancer Institute, NIH, Bethesda, MD 20892, USA Department of Surgery, University of Iowa, Iowa City, IA 52242, USA Oxford Center for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242, USADawn E. Quelle - University of IowaJames R. Howe - University of IowaYves Pommier - National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH), Bethesda, MD 20892, USA Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA National Cancer Institute, NIH, Bethesda, MD 20892, USA Department of Surgery, University of Iowa, Iowa City, IA 52242, USA Oxford Center for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242, USAJaydira del Rivero - National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (NIH), Bethesda, MD 20892, USA Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA National Cancer Institute, NIH, Bethesda, MD 20892, USA Department of Surgery, University of Iowa, Iowa City, IA 52242, USA Oxford Center for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 7LE, UK Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA University of California, San Francisco Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Cancers, Vol.14(22), p.5646
- DOI
- 10.3390/cancers14225646
- PMID
- 36428741
- PMCID
- PMC9688518
- NLM abbreviation
- Cancers (Basel)
- eISSN
- 2072-6694
- Publisher
- MDPI
- Grant note
- Intramural Research Program of the National Cancer Institute
- Language
- English
- Date published
- 11/17/2022
- Academic Unit
- Pathology; Surgery; Neuroscience and Pharmacology
- Record Identifier
- 9984319964602771
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