Journal article
Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network
Alzheimer's & dementia, Vol.19(5), pp.2150-2174
05/2023
DOI: 10.1002/alz.12941
PMCID: PMC10576242
PMID: 36799408
Abstract
Delirium is a common, morbid, and costly syndrome that is closely linked to Alzheimer's disease (AD) and AD-related dementias (ADRD) as a risk factor and outcome. Human studies of delirium have advanced our knowledge of delirium incidence and prevalence, risk factors, biomarkers, outcomes, prevention, and management. However, understanding of delirium neurobiology remains limited. Preclinical and translational models for delirium, while challenging to develop, could advance our knowledge of delirium neurobiology and inform the development of new prevention and treatment approaches. We discuss the use of preclinical and translational animal models in delirium, focusing on (1) a review of current animal models, (2) challenges and strategies for replicating elements of human delirium in animals, and (3) the utility of biofluid, neurophysiology, and neuroimaging translational markers in animals. We conclude with recommendations for the development and validation of preclinical and translational models for delirium, with the goal of advancing awareness in this important field.
Details
- Title: Subtitle
- Preclinical and translational models for delirium: Recommendations for future research from the NIDUS delirium network
- Creators
- Sarinnapha M Vasunilashorn - Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts, USANadia Lunardi - University of VirginiaJohn C Newman - Buck Institute for Research on AgingGregory Crosby - Brigham and Women's HospitalLeah Acker - Duke UniversityTed Abel - University of IowaSeema Bhatnagar - University of PennsylvaniaColm Cunningham - Trinity College DublinRafael de Cabo - National Institute on AgingLaura Dugan - Geriatric Research Education and Clinical CenterJoseph A Hippensteel - University of Colorado Anschutz Medical CampusYumiko Ishizawa - Massachusetts General HospitalShouri Lahiri - Department of Neurology, Neurosurgery, and Biomedical Sciences, Cedar-Sinai Medical Center, Los Angeles, California, USAEdward R Marcantonio - Hebrew SeniorLifeZhongcong Xie - Massachusetts General HospitalSharon K Inouye - Hebrew SeniorLifeNiccolò Terrando - Duke University School of MedicineRoderic G Eckenhoff - University of PennsylvaniaNIDUS Delirium Network
- Resource Type
- Journal article
- Publication Details
- Alzheimer's & dementia, Vol.19(5), pp.2150-2174
- DOI
- 10.1002/alz.12941
- PMID
- 36799408
- PMCID
- PMC10576242
- NLM abbreviation
- Alzheimers Dement
- eISSN
- 1552-5279
- Grant note
- R33AG071744 / NIA NIH HHS AARF-18-560786 / Alzheimer's Association K08HL159353 / NHLBI NIH HHS K01AG057836 / NIA NIH HHS AARG-22-917342 / Alzheimer's Association
- Language
- English
- Electronic publication date
- 02/17/2023
- Date published
- 05/2023
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984367951602771
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