Journal article
Predator Scent-Induced Sensitization of Hypertension and Anxiety-like Behaviors
Cellular and molecular neurobiology, Vol.42(4), pp.1141-1152
11/17/2020
DOI: 10.1007/s10571-020-01005-y
PMCID: PMC8126575
PMID: 33201417
Abstract
Post-traumatic stress disorder (PTSD), an anxiety-related syndrome, is associated with increased risk for cardiovascular diseases. The present study investigated whether predator scent (PS) stress, a model of PTSD, induces sensitization of hypertension and anxiety-like behaviors and underlying mechanisms related to renin-angiotensin systems (RAS) and inflammation. Coyote urine, as a PS stressor, was used to model PTSD. After PS exposures, separate cohorts of rats were studied for hypertensive response sensitization (HTRS), anxiety-like behaviors, and changes in plasma levels and mRNA expression of several components of the RAS and proinflammatory cytokines (PICs) in the lamina terminalis (LT), paraventricular nucleus (PVN), and amygdala (AMY). Rats exposed to PS as compared to control animals exhibited (1) a significantly greater hypertensive response (i.e., HTRS) when challenged with a slow-pressor dose of angiotensin (ANG) II, (2) significant decrease in locomotor activity and increase in time spent in the closed arms of a plus maze as well as general immobility (i.e., behavioral signs of increased anxiety), (3) upregulated plasma levels of ANG II and interleukin-6, and (4) increased expression of message for components of the RAS and PICs in key brain nuclei. All the PS-induced adverse effects were blocked by pretreatment with either an angiotensin-converting enzyme antagonist or a tumor necrosis factor-α inhibitor. The results suggest that PS, used as an experimental model of PTSD, sensitizes ANG II-induced hypertension and produces behavioral signs of anxiety, probably through upregulation of RAS components and inflammatory markers in plasma and brain areas associated with anxiety and blood pressure control.
Details
- Title: Subtitle
- Predator Scent-Induced Sensitization of Hypertension and Anxiety-like Behaviors
- Creators
- Baojian Xue - Department of Psychological and Brain Sciences, University of Iowa, PBSB, 340 Iowa Ave, Iowa City, IA, 52242, USA. baojian-xue@uiowa.eduJiarui Xue - Department of Psychological and Brain Sciences, University of Iowa, PBSB, 340 Iowa Ave, Iowa City, IA, 52242, USAYang Yu - Internal Medicine, University of Iowa, Iowa City, IA, 52242, USAShun-Guang Wei - The Franҫois M. Abboud Cardiovascular Research Center University of Iowa, Iowa City, IA, 52242, USATerry G Beltz - Department of Psychological and Brain Sciences, University of Iowa, PBSB, 340 Iowa Ave, Iowa City, IA, 52242, USARobert B Felder - The Franҫois M. Abboud Cardiovascular Research Center University of Iowa, Iowa City, IA, 52242, USAAlan Kim Johnson - The Franҫois M. Abboud Cardiovascular Research Center University of Iowa, Iowa City, IA, 52242, USA
- Resource Type
- Journal article
- Publication Details
- Cellular and molecular neurobiology, Vol.42(4), pp.1141-1152
- DOI
- 10.1007/s10571-020-01005-y
- PMID
- 33201417
- PMCID
- PMC8126575
- NLM abbreviation
- Cell Mol Neurobiol
- ISSN
- 0272-4340
- eISSN
- 1573-6830
- Publisher
- United States
- Grant note
- HL-139575 / NHLBI NIH HHS HL-139521 / NIH HHS HL-073986 / NIH HHS R01 HL139575 / NHLBI NIH HHS
- Language
- English
- Date published
- 11/17/2020
- Academic Unit
- Stead Family Department of Pediatrics; Psychological and Brain Sciences; Iowa Neuroscience Institute; Cardiovascular Medicine; Neuroscience and Pharmacology; Neurology (Pediatrics); Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984070343802771
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