Journal article
Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium
Blood, Vol.120(25), pp.4929-4937
12/13/2012
DOI: 10.1182/blood-2012-03-417253
PMCID: PMC3525019
PMID: 23074271
Abstract
Insulin-like growth factor-1 (IGF-1), insulin, and IL-6 are dysregulated in multiple myeloma pathogenesis and may also contribute to multiple myeloma etiology. To examine their etiologic role, we prospectively analyzed concentrations of serologic markers in 493 multiple myeloma cases and 978 controls from 8 cohorts in the Multiple Myeloma Cohort Consortium. We computed odds ratios (ORs) and 95% confidence intervals (CIs) for multiple myeloma per 1-SD increase in biomarker concentration using conditional logistic regression. We examined heterogeneity by time since blood collection (≤ 3, 4- ≤ 6, and > 6 years) in stratified models. Fasting IGF binding protein-1 concentration was associated with multiple myeloma risk within 3 years (OR, 95% CI per 1-SD increase: 2.3, 1.4-3.8,
P
= .001) and soluble IL-6 receptor level was associated within 6 years after blood draw (OR
≤ 3 years
, 95% CI, 1.4, 1.1-1.9,
P
= .01; OR
4- ≤ 6 years
, 95% CI, 1.4, 1.1-1.7,
P
= .002). No biomarker was associated with longer-term multiple myeloma risk (ie, > 6 years). Interactions with time were statistically significant (IGF binding protein-1,
P
-heterogeneity = .0016; sIL6R,
P
-heterogeneity = .016). The time-restricted associations probably reflect the bioactivity of tumor and microenvironment cells in transformation from monoclonal gammopathy of undetermined significance or smoldering multiple myeloma to clinically manifest multiple myeloma.
Details
- Title: Subtitle
- Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium
- Creators
- Brenda M. Birmann - Brigham and Women's HospitalMarian L. Neuhouser - University of WashingtonBernard Rosner - Brigham and Women's HospitalDemetrius Albanes - National Institutes of HealthJulie E. Buring - Harvard UniversityGraham G. Giles - Monash UniversityQing Lan - National Institutes of HealthI-Min Lee - Harvard UniversityMark P. Purdue - National Institutes of HealthNathaniel Rothman - National Institutes of HealthGianluca Severi - Cancer Council VictoriaJian-Min Yuan - UPMC Hillman Cancer CenterKenneth C. Anderson - Dana-Farber Cancer InstituteMichael Pollak - Jewish General HospitalNader Rifai - Boston Children's HospitalPatricia Hartge - National Institutes of HealthOla Landgren - National Institutes of HealthLawrence Lessin - Howard UniversityJarmo Virtamo - Finnish Institute for Health and WelfareRobert B. Wallace - University of IowaJoAnn E. Manson - Brigham and Women's HospitalGraham A. Colditz - Harvard University
- Resource Type
- Journal article
- Publication Details
- Blood, Vol.120(25), pp.4929-4937
- DOI
- 10.1182/blood-2012-03-417253
- PMID
- 23074271
- PMCID
- PMC3525019
- NLM abbreviation
- Blood
- ISSN
- 0006-4971
- eISSN
- 1528-0020
- Publisher
- American Society of Hematology
- Grant note
- R01 CA127435; K07 CA115687; P01 CA87969; R01 CA49449; P01 CA055075; P50 CA100707; CA047988; HL043851; HL080467; R01CA080205; R01CA144034; N01WH22110; 24152; 32100-2; 32105-6; 32108-9; 32111-13; 32115; 32118-32119; 32122; 42107-26; 42129-32; 44221 / National Institutes of Health
- Language
- English
- Date published
- 12/13/2012
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984364412102771
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