Journal article
Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis
Neurology, Vol.92(18), pp.e2081-e2088
04/30/2019
DOI: 10.1212/WNL.0000000000006669
PMCID: PMC6512885
PMID: 30429276
Abstract
To assess whether prediagnostic levels of plasma branched-chain amino acids (BCAAs) are associated with amyotrophic lateral sclerosis (ALS) risk.
We included participants from 5 large cohort studies-The Nurses' Health Study, the Health Professionals Follow-up Study, the Cancer Prevention Study II Nutrition, the Multiethnic Cohort Study, and the Women's Health Initiative-and identified 275 individuals who developed ALS during follow-up. Two controls were randomly selected for each case, matched on cohort, age, sex, fasting status, and time of blood draw. We measured metabolites using liquid chromatography-mass spectrometry and used conditional logistic regression to estimate rate ratios (RRs) and 95% confidence intervals (CIs) for the association of individual BCAAs with ALS risk.
None of the 3 BCAAs was associated with a higher ALS risk. The risk estimates were similar for leucine (RR top vs bottom quartile: 0.87, 95% CI 0.57-1.33), isoleucine (RR top vs bottom quartile: 0.81, 95% CI 0.52-1.24), and valine (RR top vs bottom quartile: 0.80, 95% CI 0.52-1.23) in a multivariable analysis adjusted for body mass index, smoking, level of education, and physical activity. The estimates did not vary significantly by sex, fasting status, or time interval between blood draw and disease onset.
The results from this study do not support the hypothesis that BCAAs are risk factors for ALS.
Details
- Title: Subtitle
- Prediagnostic plasma branched-chain amino acids and the risk of amyotrophic lateral sclerosis
- Creators
- Kjetil Bjornevik - Harvard UniversityÉilis J O'Reilly - University College CorkJames D Berry - Massachusetts General HospitalClary B ClishSarah Jeanfavre - The Barbara Ann Karmanos Cancer InstituteIkuko Kato - University of Hawaii SystemLaurence N Kolonel - American Cancer SocietyLoic Le Marchand - Spaulding Rehabilitation HospitalMarjorie L McCullough - Harvard UniversitySabrina Paganoni - Massachusetts General HospitalMichael A Schwarzschild - University of IowaEvelyn O Talbott - University of PittsburghRobert B WallaceZhongli ZhangJoAnn E MansonAlberto Ascherio
- Resource Type
- Journal article
- Publication Details
- Neurology, Vol.92(18), pp.e2081-e2088
- DOI
- 10.1212/WNL.0000000000006669
- PMID
- 30429276
- PMCID
- PMC6512885
- NLM abbreviation
- Neurology
- ISSN
- 0028-3878
- eISSN
- 1526-632X
- Grant note
- U01 CA167552 / NCI NIH HHS P30 ES005605 / NIEHS NIH HHS UM1 CA167552 / NCI NIH HHS U01 CA164973 / NCI NIH HHS P30 DK040561 / NIDDK NIH HHS
- Language
- English
- Date published
- 04/30/2019
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363576402771
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