Predicting hospital rates of fluoroquinolone-resistant Pseudomonas aeruginosa from fluoroquinolone use in US hospitals and their surrounding communities

Ronald E Polk; Christopher K Johnson; Donna McClish; Richard P Wenzel; Michael B Edmond

doi:10.1086/422647

Back

Predicting hospital rates of fluoroquinolone-resistant Pseudomonas aeruginosa from fluoroquinolone use in US hospitals and their surrounding communities

Journal article

Open access

Peer reviewed

Predicting hospital rates of fluoroquinolone-resistant Pseudomonas aeruginosa from fluoroquinolone use in US hospitals and their surrounding communities

Ronald E Polk, Christopher K Johnson, Donna McClish, Richard P Wenzel and Michael B Edmond

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.39(4), pp.497-503

08/15/2004

DOI: 10.1086/422647

PMID: 15356812

Files and links (1)

url

https://doi.org/10.1086/422647View

Published (Version of record) Open Access

Abstract

Rates of fluoroquinolone resistance among Pseudomonas aeruginosa in hospitals are increasing, but interhospital variability is great. We sought to determine whether this variability correlated to fluoroquinolone use in hospitals and in the surrounding community. Hospital quinolone use in 1999 (24 hospitals) through 2001 (35 hospitals) was determined from billing records. The number of fluoroquinolone prescriptions within a 10-mile (approximately 16-km) radius of each hospital was determined for 1999 and 2000. Hospital fluoroquinolone use increased from 1999 through 2001, from 137 to 163 defined daily doses (DDD)/1000 patient-days (P=.01). The rate of community fluoroquinolone use also increased, from 2.3 to 2.8 DDD/1000 inhabitant-days (P<.001). Rates of fluoroquinolone-resistant P. aeruginosa increased from 29% in 1999 to 36% in 2001 (P=.003). Both community and hospital fluoroquinolone use were predictive of rates of fluoroquinolone-resistant P. aeruginosa. Levofloxacin was associated with resistance, but ciprofloxacin was not. Most of the variability in resistance rates is explained by volume of fluoroquinolone use, both in the hospital and the surrounding community.

Length of Stay

Predictive Value of Tests

United States - epidemiology

Community-Acquired Infections - epidemiology

Pseudomonas Infections - drug therapy

Humans

Middle Aged

Fluoroquinolones - therapeutic use

Pseudomonas aeruginosa - drug effects

Infection Control - methods

Communicable Disease Control - methods

Microbial Sensitivity Tests

Anti-Bacterial Agents - therapeutic use

Pseudomonas Infections - metabolism

Fluoroquinolones - metabolism

Adolescent

Adult

Female

Anti-Bacterial Agents - adverse effects

Drug Resistance, Bacterial - drug effects

Population Surveillance - methods

Cross Infection - epidemiology

Details

Title: Subtitle: Predicting hospital rates of fluoroquinolone-resistant Pseudomonas aeruginosa from fluoroquinolone use in US hospitals and their surrounding communities
Creators: Ronald E Polk - School of Pharmacy, Department of Pharmacy, Virginia Commonwealth University, Medical College of Virginia Campus, Richmond, VA 23298, USA. rpolk@hsc.vcu.edu
Christopher K Johnson
Donna McClish
Richard P Wenzel
Michael B Edmond
Resource Type: Journal article
Publication Details: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol.39(4), pp.497-503
DOI: 10.1086/422647
PMID: 15356812
NLM abbreviation: Clin Infect Dis
ISSN: 1058-4838
eISSN: 1537-6591
Publisher: United States
Language: English
Date published: 08/15/2004
Academic Unit: Infectious Diseases; Internal Medicine
Record Identifier: 9983905644302771

Metrics

19 Record Views

102 Times Cited - Web of Science