Journal article
Predicting sensation seeking from dopamine genes: A candidate system approach
Psychological science, Vol.21(9), pp.1282-1290
09/2010
DOI: 10.1177/0956797610380699
PMCID: PMC3031097
PMID: 20732903
Abstract
Sensation seeking is a heritable personality trait that has been reliably linked to behavior disorders. The dopamine system has been hypothesized to contribute to individual differences in sensation seeking, and both experimental and observational studies in humans and non-human animals provide evidence for this relationship. We present here a candidate-system approach to genetic association analysis of sensation seeking, in which single nucleotide polymorphisms (SNPs) from a number of dopaminergic genes were analyzed. Using 273 SNPs from eight dopamine genes in a sample of 635 unrelated individuals, we examined the aggregate effects of those SNPs significantly associated with sensation seeking. Multiple SNPs in four dopamine genes accounted for significant variance in sensation seeking. These results suggest that aggregation of multiple SNPs within genes relevant to a specific neurobiological system into a “genetic risk score” may explain a nontrivial proportion of variance in human traits.
Details
- Title: Subtitle
- Predicting sensation seeking from dopamine genes: A candidate system approach
- Creators
- Jaime Derringer - Washington University in St. LouisRobert F Krueger - Washington University in St. LouisDanielle M Dick - Virginia Institute for Psychiatric and Behavioral GeneticsScott Saccone - Washington University in St. LouisRichard A Grucza - Washington University in St. LouisArpana Agrawal - Washington University in St. LouisPeng Lin - Washington University in St. LouisLaura Almasy - Southwest FoundationHoward J Edenberg - Indiana UniversityTatiana Foroud - Indiana UniversityJohn I Nurnberger - Indiana UniversityVictor M Hesselbrock - University of ConnecticutJohn R Kramer - University of IowaSamuel Kuperman - University of IowaBernice Porjesz - SUNY DownstateMarc A Schuckit - University of California at San DiegoGene Environment Association Studies ConsortiumLaura J Bierut - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Psychological science, Vol.21(9), pp.1282-1290
- DOI
- 10.1177/0956797610380699
- PMID
- 20732903
- PMCID
- PMC3031097
- NLM abbreviation
- Psychol Sci
- ISSN
- 0956-7976
- eISSN
- 1467-9280
- Language
- English
- Date published
- 09/2010
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984004192002771
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