Journal article
Prediction of acute respiratory disease in current and former smokers with and without COPD
Chest, Vol.146(4), pp.941-950
10/2014
DOI: 10.1378/chest.13-2946
PMCID: PMC4188150
PMID: 24945159
Abstract
The risk factors for acute episodes of respiratory disease in current and former smokers who do not have COPD are unknown.
Eight thousand two hundred forty-six non-Hispanic white and black current and former smokers in the Genetic Epidemiology of COPD (COPDGene) cohort had longitudinal follow-up (LFU) every 6 months to determine acute respiratory episodes requiring antibiotics or systemic corticosteroids, an ED visit, or hospitalization. Negative binomial regression was used to determine the factors associated with acute respiratory episodes. A Cox proportional hazards model was used to determine adjusted hazard ratios (HRs) for time to first episode and an acute episode of respiratory disease risk score.
At enrollment, 4,442 subjects did not have COPD, 658 had mild COPD, and 3,146 had moderate or worse COPD. Nine thousand three hundred three acute episodes of respiratory disease and 2,707 hospitalizations were reported in LFU (3,044 acute episodes of respiratory disease and 827 hospitalizations in those without COPD). Major predictors included acute episodes of respiratory disease in year prior to enrollment (HR, 1.20; 95% CI, 1.15-1.24 per exacerbation), airflow obstruction (HR, 0.94; 95% CI, 0.91-0.96 per 10% change in % predicted FEV1), and poor health-related quality of life (HR, 1.07; 95% CI, 1.06-1.08 for each 4-unit increase in St. George's Respiratory Questionnaire score). Risks were similar for those with and without COPD.
Although acute episode of respiratory disease rates are higher in subjects with COPD, risk factors are similar, and at a population level, there are more episodes in smokers without COPD.
Details
- Title: Subtitle
- Prediction of acute respiratory disease in current and former smokers with and without COPD
- Creators
- Russell P Bowler - Department of Medicine, National Jewish Health, Denver, CO. Electronic address: Bowlerr@njhealth.orgVictor Kim - Department of Medicine, Section of Pulmonary and Critical Care Medicine, Temple University, Philadelphia PAElizabeth Regan - Department of Medicine, National Jewish Health, Denver, COAndré A A Williams - Department of Medicine, National Jewish Health, Denver, COStephanie A Santorico - Department of Mathematical and Statistical Sciences, University of Colorado Denver, Denver, COBarry J Make - Department of Medicine, National Jewish Health, Denver, CODavid A Lynch - Department of Medicine, National Jewish Health, Denver, COJohn E Hokanson - Department of Medicine and the Department of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, COGeorge R Washko - Channing Division of Network Medicine, Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women's Hospital, Boston, MAPeter Bercz - Department of Medicine, Section of Pulmonary and Critical Care Medicine, Temple University, Philadelphia PAXavier Soler - Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California at San Diego, La Jolla, CANathaniel Marchetti - Department of Medicine, Section of Pulmonary and Critical Care Medicine, Temple University, Philadelphia PAGerard J Criner - Department of Medicine, Section of Pulmonary and Critical Care Medicine, Temple University, Philadelphia PAJoe Ramsdell - Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California at San Diego, La Jolla, CAMeiLan K Han - Department of Internal Medicine, University of Michigan, Ann Arbor, MIDawn Demeo - Channing Division of Network Medicine, Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women's Hospital, Boston, MAAntonio Anzueto - Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center, and South Texas Veterans Health Care System, San Antonio, TXAlejandro Comellas - University of Iowa, Iowa City, IAJames D Crapo - Department of Medicine, National Jewish Health, Denver, COMark Dransfield - University of Alabama at Birmingham, Birmingham, ALJ Michael Wells - University of Alabama at Birmingham, Birmingham, ALCraig P Hersh - Channing Division of Network Medicine, Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women's Hospital, Boston, MANeil MacIntyre - Duke University Medical Center, Durham, NCFernando Martinez - Department of Internal Medicine, University of Michigan, Ann Arbor, MIHrudaya P Nath - University of Alabama at Birmingham, Birmingham, ALDennis Niewoehner - University of Minnesota, Minneapolis, MNFrank Sciurba - University of Pittsburgh Medical Center, Pittsburgh, PAAmir Sharafkhaneh - Baylor College of Medicine, Houston, TXEdwin K Silverman - Channing Division of Network Medicine, Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women's Hospital, Boston, MAEdwin J R van Beek - Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, ScotlandCarla Wilson - Division of Biostatistics and Bioinformatics, National Jewish Health, Denver, COChristine Wendt - University of Minnesota, Minneapolis, MNRobert A Wise - Johns Hopkins University, Baltimore, MDCOPDGene Investigators
- Resource Type
- Journal article
- Publication Details
- Chest, Vol.146(4), pp.941-950
- DOI
- 10.1378/chest.13-2946
- PMID
- 24945159
- PMCID
- PMC4188150
- ISSN
- 0012-3692
- eISSN
- 1931-3543
- Grant note
- R01 NR013377 / NINR NIH HHS UL1 TR001082 / NCATS NIH HHS R01 HL089856 / NHLBI NIH HHS R01 HL 08 9897 / NHLBI NIH HHS NR013377 / NINR NIH HHS R01 HL 08 9856 / NHLBI NIH HHS UL1 RR025780 / NCRR NIH HHS R01 HL089897 / NHLBI NIH HHS UL1 TR000005 / NCATS NIH HHS G0701127 / Medical Research Council
- Language
- English
- Date published
- 10/2014
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; ICTS; Internal Medicine
- Record Identifier
- 9984094344302771
Metrics
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