Prediction of hospital admissions and grade 3-4 toxicities in cancer patients 70 years old and older receiving chemotherapy

Melissa Reed; Caitlyn Patrick; Travis Quevillon; Natalie Walde; Ioannis A Voutsadakis

doi:10.1111/ecc.13144

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Prediction of hospital admissions and grade 3-4 toxicities in cancer patients 70 years old and older receiving chemotherapy

Journal article

Peer reviewed

Prediction of hospital admissions and grade 3-4 toxicities in cancer patients 70 years old and older receiving chemotherapy

Melissa Reed, Caitlyn Patrick, Travis Quevillon, Natalie Walde and Ioannis A Voutsadakis

European journal of cancer care, Vol.28(6), pp.e13144-n/a

11/2019

DOI: 10.1111/ecc.13144

PMID: 31429128

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Abstract

To predict chemotherapy toxicity and hospitalisations in elderly patients using clinical and laboratory parameters. Records of cancer patients 70 years old or older who received adjuvant chemotherapy or first-line chemotherapy for a cancer in a single centre were reviewed. Factors associated with hospitalisations, grade 3-4 toxicities and dose reductions during treatment were evaluated. A total of 275 patients included in the study. Most patients (53.8%) were 70 to 75 years old. One hundred and five patients (38.2%) had a hospital admission during or within a month after their chemotherapy treatment. The only factor associated with admissions in the multivariate analysis was ECOG performance status (PS) >1 (p = .008, odds ratio 2.66, 95% CI: 1.28-5.53) and hypoalbuminaemia approached significance. Grade 3 and 4 toxicities were associated with a lower creatinine clearance in the multivariate analysis (p = .01, odds ratio 0.98, 95% CI: 0.97-1.0), and dose reductions were associated with metastatic stage (p = .03, odds ratio 1.88, 95% CI: 1.05-3.35). A combined index with all four parameters was associated with all three outcomes of interest. ECOG PS, stage, albumin and creatinine clearance may be predictive of hospital admissions, grade 3-4 toxicities and dose reduction rates in cancer patients 70 years old and older receiving chemotherapy.

Age Factors

Aged

Aged, 80 and over

Antineoplastic Agents - adverse effects

Antineoplastic Agents - therapeutic use

Antineoplastic Combined Chemotherapy Protocols - adverse effects

Antineoplastic Combined Chemotherapy Protocols - therapeutic use

Chemotherapy, Adjuvant - adverse effects

Dose-Response Relationship, Drug

Female

Hospitalization - statistics & numerical data

Humans

Male

Multivariate Analysis

Neoplasms - drug therapy

Prognosis

Details

Title: Subtitle: Prediction of hospital admissions and grade 3-4 toxicities in cancer patients 70 years old and older receiving chemotherapy
Creators: Melissa Reed - Sault Area Hospital
Caitlyn Patrick - Sault Area Hospital
Travis Quevillon - Sault Area Hospital
Natalie Walde - Sault Area Hospital
Ioannis A Voutsadakis - NOSM University
Resource Type: Journal article
Publication Details: European journal of cancer care, Vol.28(6), pp.e13144-n/a
DOI: 10.1111/ecc.13144
PMID: 31429128
ISSN: 0961-5423
eISSN: 1365-2354
Grant note: NA / Sault Ste Marie Academic Medical Association
Language: English
Date published: 11/2019
Academic Unit: Internal Medicine
Record Identifier: 9984806506302771

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