Prediction of post-operative necrosis after mastectomy: a pilot study utilizing optical diffusion imaging spectroscopy

Roshni Rao; Michel Saint-Cyr; Aye Moe Thu Ma; Monet Bowling; Daniel A Hatef; Valerie Andrews; Xian-Jin Xie; Theresa Zogakis; Rod Rohrich

doi:10.1186/1477-7819-7-91

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Prediction of post-operative necrosis after mastectomy: a pilot study utilizing optical diffusion imaging spectroscopy

Journal article

Open access

Peer reviewed

Prediction of post-operative necrosis after mastectomy: a pilot study utilizing optical diffusion imaging spectroscopy

Roshni Rao, Michel Saint-Cyr, Aye Moe Thu Ma, Monet Bowling, Daniel A Hatef, Valerie Andrews, Xian-Jin Xie, Theresa Zogakis and Rod Rohrich

World journal of surgical oncology, Vol.7(1), 91

11/25/2009

DOI: 10.1186/1477-7819-7-91

PMCID: PMC2788547

PMID: 19939277

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Abstract

Flap necrosis and epidermolysis occurs in 18-30% of all mastectomies. Complications may be prevented by intra-operative detection of ischemia. Currently, no technique enables quantitative valuation of mastectomy skin perfusion. Optical Diffusion Imaging Spectroscopy (ViOptix T.Ox Tissue Oximeter) measures the ratio of oxyhemoglobin to deoxyhemoglobin over a 1 x 1 cm area to obtain a non-invasive measurement of perfusion (StO2). This study evaluates the ability of ViOptix T.Ox Tissue Oximeter to predict mastectomy flap necrosis. StO2 measurements were taken at five points before and at completion of dissection in 10 patients. Data collected included: demographics, tumor size, flap length/thickness, co-morbidities, procedure length, and wound complications. One patient experienced mastectomy skin flap necrosis. Five patients underwent immediate reconstruction, including the patient with necrosis. Statistically significant factors contributing to necrosis included reduction in medial flap StO2 (p = 0.0189), reduction in inferior flap StO2 (p = 0.003), and flap length (p = 0.009). StO2 reductions may be utilized to identify impaired perfusion in mastectomy skin flaps.

Breast Neoplasms - surgery

Optical Devices

Prognosis

Humans

Middle Aged

Survival Rate

Treatment Outcome

Oxygen - metabolism

Necrosis

Pilot Projects

Postoperative Care

Surgical Flaps - pathology

Breast Neoplasms - pathology

Diffusion Magnetic Resonance Imaging

Mastectomy

Female

Skin - pathology

Details

Title: Subtitle: Prediction of post-operative necrosis after mastectomy: a pilot study utilizing optical diffusion imaging spectroscopy
Creators: Roshni Rao - Department of Surgery, Division of Surgical Oncology, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9155, USA. Roshni.Rao@utsouthwestern.edu
Michel Saint-Cyr
Aye Moe Thu Ma
Monet Bowling
Daniel A Hatef
Valerie Andrews
Xian-Jin Xie
Theresa Zogakis
Rod Rohrich
Resource Type: Journal article
Publication Details: World journal of surgical oncology, Vol.7(1), 91
Publisher: England
DOI: 10.1186/1477-7819-7-91
PMID: 19939277
PMCID: PMC2788547
ISSN: 1477-7819
eISSN: 1477-7819
Language: English
Date published: 11/25/2009
Academic Unit: Preventive and Community Dentistry; Biostatistics; Dental Research
Record Identifier: 9983917660902771

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