Predictive Ability of Childhood Metabolic Components for Adult Metabolic Syndrome and Type 2 Diabetes

Christine M. Schubert; Shumei S. Sun; Trudy L. Burns; John A. Morrison; Terry T.-K. Huang

doi:10.1016/j.jpeds.2009.04.048

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Predictive Ability of Childhood Metabolic Components for Adult Metabolic Syndrome and Type 2 Diabetes

Journal article

Open access

Peer reviewed

Predictive Ability of Childhood Metabolic Components for Adult Metabolic Syndrome and Type 2 Diabetes

Christine M. Schubert, Shumei S. Sun, Trudy L. Burns, John A. Morrison and Terry T.-K. Huang

The Journal of pediatrics, Vol.155(3), pp.S6.e1-S6.e7

2009

DOI: 10.1016/j.jpeds.2009.04.048

PMCID: PMC3777811

PMID: 19732565

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https://www.ncbi.nlm.nih.gov/pmc/articles/3777811View

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Abstract

To estimate sensitivity, specificity, and positive and negative predictive values of components of the metabolic syndrome (MetS) during childhood for MetS and type 2 diabetes (T2D) in adulthood. Data from 3 major studies—the Fels Longitudinal Study, the Muscatine Study, and the Princeton Follow-up Study—were combined to examine how thresholds of metabolic components during childhood determine adult MetS and T2D. Available metabolic components examined in the 1789 subjects included high-density lipoprotein, triglyceride levels, glucose, and percentiles for body mass index, waist circumference, triglycerides, and systolic and diastolic blood pressures. Sensitivity, specificity, and positive and negative predictive values for a refined set of component threshold values were examined individually and in combination. Sensitivity and positive predictive values remained low for adult MetS and T2D for individual components. However, specificity and negative predictive values were fairly high for MetS and exceptionally so for T2D. In combination, having 1 or more of the components showed the highest sensitivity over any individual component and high negative predictive value. Overall, specificity and negative predictive values remained high whether considering individual or combined components for T2D. Sensitivity and positive predictive values on the basis of childhood measures remained relatively low, but specificity and negative predictive values were consistently higher, especially for T2D. This indicates that these components, when examined during childhood, may provide a useful screening approach to identifying children not at risk so that further attention can be focused on those who may be in need of future intervention.

SBP

HDL

DBP

MetS

NPV

Master of Science (MS)

PPV

T2D

FLS

PFS

ATP

BMI

Details

Title: Subtitle: Predictive Ability of Childhood Metabolic Components for Adult Metabolic Syndrome and Type 2 Diabetes
Creators: Christine M. Schubert - Virginia Commonwealth University
Shumei S. Sun - Virginia Commonwealth University
Trudy L. Burns - University of Iowa
John A. Morrison - Cincinnati Children's Hospital Medical Center
Terry T.-K. Huang - Eunice Kennedy Shriver National Institute of Child Health and Human Development
Resource Type: Journal article
Publication Details: The Journal of pediatrics, Vol.155(3), pp.S6.e1-S6.e7
DOI: 10.1016/j.jpeds.2009.04.048
PMID: 19732565
PMCID: PMC3777811
NLM abbreviation: J Pediatr
ISSN: 0022-3476
eISSN: 1097-6833
Publisher: Mosby, Inc
Language: English
Date published: 2009
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984364398302771

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