Journal article
Predictive Model for Positive Video Capsule Endoscopy in Iron Deficiency Anemia
Digestive diseases and sciences, Vol.68(7), pp.3083-3091
07/2023
DOI: 10.1007/s10620-023-07918-0
PMID: 36917313
Abstract
Bleeding from the gastrointestinal tract can contribute to the development of iron deficiency anemia (IDA) among individuals without another obvious source of bleeding. In order to identify patients most likely to benefit from examination of the small bowel, our aim was to create a risk score for positive video capsule endoscopy (VCE) in IDA utilizing a multicenter collection of studies.
We performed a retrospective multicenter study utilizing VCE studies performed for an indication of IDA between 1/1/2005 and 7/31/2018. VCE findings were graded based on the P0-P2 grading system. The primary outcome of interest was a positive (P2) VCE. Data were analyzed with Student's t test for continuous variables and the Fisher's exact test for categorical variables. Logistic regression was used to identify independent associations with positive VCE.
In total, 765 VCE procedures were included with 355 (46.5%) male subjects and a median age of 63.2 (SD 15.3) years. One hundred ninety studies (24.8%) were positive (P2) for small bowel bleeding. Four variables associated with positive VCE which were incorporated into a point scoring system: (+) 1 for age ≥ 66 years, active smoking and cardiac arrythmia and (-) 1 for preceding hemoglobin level ≥ 8.5. The risk probabilities for positive VCE-assigned scores - 1, 0, 1, and 2 + were 12.3% (95% CI 7.3-17.3%), 20% (14.9-25.1%), 34.8% (28.6-41%), and 39% (30-47.8%).
In order to improve the diagnostic yield of capsule examinations, risk factors should be applied to clinical decision-making. We created a risk score for positive VCE in IDA, including the risk factors of age, smoking, history of cardiac arrythmia, and preceding hemoglobin level.
Details
- Title: Subtitle
- Predictive Model for Positive Video Capsule Endoscopy in Iron Deficiency Anemia
- Creators
- Shadi Hamdeh - University of Kansas Medical CenterJihan Fathallah - University of Kansas Medical CenterHui Zhang - University of ChicagoAmber Charoen - Johns Hopkins MedicineBarakat Aburajab Altamimi - University of Iowa Hospitals and ClinicsFlorence-Damilola Odufalu - Saint Louis UniversityDevashree Dave - University of Iowa Hospitals and ClinicsAmer El Sayed - Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa Hospital and Clinics, Iowa City, IA, USALaura R Glick - University of ChicagoScott Grisolano - University of Kansas Medical CenterChristine Hachem - Saint Louis UniversityMuhammad Bader Hammami - Saint Louis UniversityKhaldoun Haj Mahmoud - University of Kansas Medical CenterAlexander N Levy - Tufts Medical CenterVijaya L Rao - University of ChicagoHong Gi Shim - Tufts Medical CenterCarol Semrad - University of ChicagoMojtaba Olyaee - University of Kansas Medical CenterDejan Micic - University of Chicago
- Resource Type
- Journal article
- Publication Details
- Digestive diseases and sciences, Vol.68(7), pp.3083-3091
- DOI
- 10.1007/s10620-023-07918-0
- PMID
- 36917313
- ISSN
- 0163-2116
- eISSN
- 1573-2568
- Language
- English
- Electronic publication date
- 03/14/2023
- Date published
- 07/2023
- Academic Unit
- Gastroenterology and Hepatology; Internal Medicine
- Record Identifier
- 9984378333702771
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