Predictive utility of the P3 event‐related potential (ERP) response to alcohol cues for ecologically assessed alcohol craving and use

Casey B. Kohen; Roberto U. Cofresí; Thomas M. Piasecki; Bruce D. Bartholow

doi:10.1111/adb.13368

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Predictive utility of the P3 event‐related potential (ERP) response to alcohol cues for ecologically assessed alcohol craving and use

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Predictive utility of the P3 event‐related potential (ERP) response to alcohol cues for ecologically assessed alcohol craving and use

Casey B. Kohen, Roberto U. Cofresí, Thomas M. Piasecki and Bruce D. Bartholow

Addiction biology, Vol.29(2), e13368

02/2024

DOI: 10.1111/adb.13368

PMCID: PMC10882185

PMID: 38380714

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Abstract

Abstract Neural measures of alcohol cue incentive salience have been associated with retrospective reports of riskier alcohol use behaviour and subjective response profiles. This study tested whether the P3 event‐related potential (ERP) elicited by alcohol‐related cues (ACR‐P3) can forecast alcohol use and craving during real‐world drinking episodes. Participants ( N = 262; M age = 19.53; 56% female) completed a laboratory task in which they viewed images of everyday objects (Neutral), non‐alcohol drinks (NonAlc) and alcohol beverages (Alc) while EEG was recorded and then completed a 21‐day ecological momentary assessment (EMA) protocol in which they recorded alcohol craving and consumption. Anthropometrics were used to derive estimated blood alcohol concentration (eBAC) throughout drinking episodes. Multilevel modelling indicated positive associations between P3 amplitudes elicited by all stimuli and within‐episode alcohol use measures (e.g., eBAC, cumulative drinks). Focal follow‐up analyses indicated a positive association between AlcP3 amplitude and eBAC within episodes: Larger AlcP3 was associated with a steeper rise in eBAC. This association was robust to controlling for the association between NonAlcP3 and eBAC. AlcP3 also was positively associated with episode‐level measures (e.g., max drinks, max eBAC). There were no associations between any P3 variables and EMA‐based craving measures. Thus, individual differences in neural measures of alcohol cue incentive salience appear to predict the speed and intensity of alcohol consumption but not reports of craving during real‐world alcohol use episodes.

Details

Title: Subtitle: Predictive utility of the P3 event‐related potential (ERP) response to alcohol cues for ecologically assessed alcohol craving and use
Creators: Casey B. Kohen - University of Missouri
Roberto U. Cofresí - University of Missouri
Thomas M. Piasecki - University of Wisconsin–Madison
Bruce D. Bartholow - University of Iowa
Resource Type: Journal article
Publication Details: Addiction biology, Vol.29(2), e13368
DOI: 10.1111/adb.13368
PMID: 38380714
PMCID: PMC10882185
NLM abbreviation: Addict Biol
ISSN: 1355-6215
eISSN: 1369-1600
Grant note: DOI: 10.13039/100000002, name: National Institutes of Health, award: K99AA029169, AA025451‐04S1, AA013526, R01AA025451
Language: English
Date published: 02/2024
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984557859802771

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