Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral joint – the MOST study

F.W Roemer; M.C Nevitt; D.T Felson; J Niu; J.A Lynch; M.D Crema; C.E Lewis; J Torner; A Guermazi

doi:10.1016/j.joca.2012.07.012

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Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral joint – the MOST study

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Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral joint – the MOST study

F.W Roemer, M.C Nevitt, D.T Felson, J Niu, J.A Lynch, M.D Crema, C.E Lewis, J Torner and A Guermazi

Osteoarthritis and cartilage, Vol.20(11), pp.1391-1398

11/2012

DOI: 10.1016/j.joca.2012.07.012

PMCID: PMC3863692

PMID: 22846715

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Abstract

In order to increase sensitivity to detect longitudinal change, recording of within-grade changes was introduced for cartilage morphology and bone marrow lesion (BML) assessment in semiquantitative magnetic resonance imaging (MRI) scoring of knee osteoarthritis (OA). The aim of this study was to examine the validity provided by within-grade scoring. The Multicenter Osteoarthritis (MOST) study is a longitudinal study of subjects with or at risk of knee OA. Baseline and 30 months MRIs were read according to the modified Whole-Organ Magnetic Resonance Imaging Score (WORMS) system including within-grade changes for cartilage and BMLs. We tested the validity of within-grade changes by whether the 30-month changes in cartilage and BML assessment were predicted by baseline ipsi-compartmental meniscal damage and malalignment, factors known to affect cartilage loss and BMLs, using ordinal logistic regression. 1867 Knees (from 1411 participants) were included. Severe medial meniscal damage predicted partial grade (adjusted odds ratio (aOR) 4.4, 95% confidence interval (95% CI) 2.2, 8.7) but not ≥full grade (aOR 1.3, 95% CI 0.8, 2.2) worsening of cartilage loss and predicted both, partial grade (aOR 9.6, 95% CI 3.6, 25.1) and ≥full grade (aOR 5.1, 95% CI 3.2, 8.2) worsening of BMLs. Severe, but not moderate, malalignment predicted ipsi-compartmental within-grade (medial cartilage damage: aOR 5.5, 95% CI 2.6, 11.6; medial worsening of BMLs: aOR 4.9, 95% CI 2.0, 12.3) but not full grade worsening of BMLs and cartilage damage. Within-grade changes in semiquantitative MRI assessment of cartilage and BMLs are valid and their use may increase the sensitivity of semiquantitative readings in detecting longitudinal changes in these structures.

Validity

Semiquantitative scoring

MRI

Osteoarthritis

Within grade

WORMS

Details

Title: Subtitle: Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral joint – the MOST study
Creators: F.W Roemer - Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA, USA
M.C Nevitt - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
D.T Felson - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
J Niu - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA
J.A Lynch - Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
M.D Crema - Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA, USA
C.E Lewis - Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
J Torner - Department of Epidemiology at the University of Iowa, Iowa City, IA, USA
A Guermazi - Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA, USA
Resource Type: Journal article
Publication Details: Osteoarthritis and cartilage, Vol.20(11), pp.1391-1398
DOI: 10.1016/j.joca.2012.07.012
PMID: 22846715
PMCID: PMC3863692
NLM abbreviation: Osteoarthritis Cartilage
ISSN: 1063-4584
eISSN: 1522-9653
Publisher: Elsevier Ltd
Language: English
Date published: 11/2012
Academic Unit: Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
Record Identifier: 9983995118702771

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