Predictive value of 1 month retinal nerve fiber layer thinning for deficits at 6 months after acute optic neuritis

Mark J Kupersmith; Susan Anderson; Randy Kardon

doi:10.1177/1352458513485149

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Predictive value of 1 month retinal nerve fiber layer thinning for deficits at 6 months after acute optic neuritis

Journal article

Peer reviewed

Predictive value of 1 month retinal nerve fiber layer thinning for deficits at 6 months after acute optic neuritis

Mark J Kupersmith, Susan Anderson and Randy Kardon

Multiple sclerosis, Vol.19(13), pp.1743-1748

11/2013

DOI: 10.1177/1352458513485149

PMID: 23698127

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Abstract

Retinal nerve fiber layer (RNFL) loss occurs with multiple sclerosis and after optic neuritis. Vision or RNFL changes at presentation of optic neuritis are not predictive of outcome, but vision loss at 1 month correlates with vision deficits at 6 months. We hypothesized that RFNL thinning at 1 month would predict RNFL loss at 6 months. We prospectively studied the RNFL by optical coherence tomography (OCT) and scanning laser polarimetry (SLP), and determined the threshold field mean deviation, in 25 subjects with acute optic neuritis over a 6-month period. RNFL values, including the amount of thinning at 1-month, were correlated with 6-month outcome. Baseline visual performance and RNFL values were similar for eyes grouped by 1 month RNFL thinning. Eyes with 1 month RNFL thinning had greater and significant RNFL thinning at 6 months, for all quadrants by OCT and for the nasal and inferior quadrants by SLP. RNFL thinning by OCT and SLP at 1 month correlated with 6-month OCT (r = 0.58; p = 0.006) and SLP (r = 0.59; p = 0.002) RNFL thinning, respectively. Early RNFL loss at 1 month was predictive of the RNFL thinning at 6 months, which corroborated the importance of the 1-month time point for predicting the outcome of an optic neuritis attack.

Optic Nerve - pathology

Predictive Value of Tests

Acute Disease

Prospective Studies

Tomography, Optical Coherence

Humans

Male

Treatment Outcome

Vision Tests

Scanning Laser Polarimetry

Adult

Female

Optic Neuritis - pathology

Retina - pathology

Optic Neuritis - complications

Vision Disorders - etiology

Details

Title: Subtitle: Predictive value of 1 month retinal nerve fiber layer thinning for deficits at 6 months after acute optic neuritis
Creators: Mark J Kupersmith - Institute of Neurology and Neurosurgery (INN), Roosevelt Hospital, New York, NY, USA
Susan Anderson
Randy Kardon
Resource Type: Journal article
Publication Details: Multiple sclerosis, Vol.19(13), pp.1743-1748
DOI: 10.1177/1352458513485149
PMID: 23698127
NLM abbreviation: Mult Scler
ISSN: 1477-0970
eISSN: 1477-0970
Publisher: England
Language: English
Date published: 11/2013
Academic Unit: Iowa Neuroscience Institute; Ophthalmology and Visual Sciences
Record Identifier: 9983979971702771

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