Journal article
Predictors and Impact of Pneumonia on Adverse Outcomes in Inhalation Injury Patients
Journal of burn care & research, Vol.44(6), pp.1289-1297
11/02/2023
DOI: 10.1093/jbcr/irad099
PMID: 37352120
Abstract
Inhalation injury (II) is the third mortality prognostic factor for burn injury following age and burn size. II can lead to pulmonary complications such as pneumonia and acute respiratory distress syndrome (ARDS); all of which have been hypothesized to increase morbidity and mortality in II. Herein, we aimed to identify variables associated with the risk of developing pneumonia and to determine the impact of pneumonia on selected II outcomes. De-identified data from the Prospective Inhalation Study titled Inhalation Injury Scoring System to Predict Inhalation Injury Severity (ISIS) were used. II was confirmed by fiberoptic bronchoscopy. Demographics, injury, and hospital course information were recorded. P < .05 was considered significant. One hundred subjects were included. On univariate analysis, pneumonia was associated with burn severity, race, and receipt of colloid during the first 24 hours. Patients who developed pneumonia spent more time on a ventilator, had longer hospitalizations (LOS) and were more likely to need a tracheostomy. On multivariate analysis, total number of ventilator days was associated with pneumonia (Odd ratio (OR) = 1.122 [1.048-1.200], P = .001). Both pneumonia and receipt of colloid were predictive of increased ventilator days (OR = 2.545 [1.363-4.753], P < .001 and OR = 2.809 [1.548-5.098], P < .001, respectively). Pneumonia was not an independent predictor of LOS, ARDS, or mortality. Pneumonia remains a high-risk complication associated with two times more ventilator days in II. Future research should focus on prevention of pneumonia and the relationship between colloid fluids and pneumonia and early ventilator liberation in II patients.
Details
- Title: Subtitle
- Predictors and Impact of Pneumonia on Adverse Outcomes in Inhalation Injury Patients
- Creators
- Nicolas C. Ronkar - University of Iowa, SurgeryColette Galet - University of IowaKaren Richey - Maricopa Cty Burn Ctr, Phoenix, AZ USAKevin Foster - Maricopa County Department of Public HealthLucy Wibbenmeyer - University of Iowa, Surgery
- Resource Type
- Journal article
- Publication Details
- Journal of burn care & research, Vol.44(6), pp.1289-1297
- DOI
- 10.1093/jbcr/irad099
- PMID
- 37352120
- NLM abbreviation
- J Burn Care Res
- ISSN
- 1559-047X
- eISSN
- 1559-0488
- Publisher
- Oxford Univ Press
- Number of pages
- 9
- Grant note
- American Burn association U.S. Army Medical Research and Development Command; United States Department of Defense; United States Army; United States Army Medical Research & Development Command (USAMRDC)
- Language
- English
- Electronic publication date
- 06/23/2023
- Date published
- 11/02/2023
- Academic Unit
- Surgery; Injury Prevention Research Center; University of Iowa Health Care
- Record Identifier
- 9984473209202771
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