Predictors of Adherence in the Women's Health Initiative Calcium and Vitamin D Trial

R Brunner; J Dunbar-Jacob; M. S LeBoff; I Granek; D Bowen; L. G Snetselaar; S. A Shumaker; J Ockene; M Rosal; J Wactawski-Wende; J Cauley; B Cochrane; L Tinker; R Jackson; C. Y Wang; L Wu

doi:10.3200/BMED.34.4.145-155

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Predictors of Adherence in the Women's Health Initiative Calcium and Vitamin D Trial

Journal article

Peer reviewed

Predictors of Adherence in the Women's Health Initiative Calcium and Vitamin D Trial

R Brunner, J Dunbar-Jacob, M. S LeBoff, I Granek, D Bowen, L. G Snetselaar, S. A Shumaker, J Ockene, M Rosal, J Wactawski-Wende, …

Behavioral Medicine, Vol.34(4), pp.145-155

01/01/2009

DOI: 10.3200/BMED.34.4.145-155

PMCID: PMC3770154

PMID: 19064373

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https://www.ncbi.nlm.nih.gov/pmc/articles/3770154View

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Abstract

The authors analyzed data from the Women's Health Initiative (WHI) Calcium and Vitamin D Supplementation Trial (CaD) to learn more about factors affecting adherence to clinical trial study pills (both active and placebo). Most participants (36,282 postmenopausal women aged 50-79 years) enrolled in CaD 1 year after joining either a hormone trial or the dietary modification trial of WHI. The WHI researchers measured adherence to study pills by weighing the amount of remaining pills at an annual study visit; adherence was primarily defined as taking ≥ 80% of the pills. The authors in this study examined a number of behavioral, demographic, procedural, and treatment variables for association with study pill adherence. They found that relatively simple procedures (ie, phone contact early in the study [4 weeks post randomization] and direct social contact) later in the trial may improve adherence. Also, at baseline, past pill-use experiences, personal supplement use, and relevant symptoms may be predictive of adherence in a supplement trial.

clinical trial

calcium supplementation

adherence

women

Details

Title: Subtitle: Predictors of Adherence in the Women's Health Initiative Calcium and Vitamin D Trial
Creators: R Brunner - Department of Family and Community Medicine, University of Nevada School of Medicine, Reno
J Dunbar-Jacob - University of Pittsburgh School of Nursing, Pittsburgh, PA
M. S LeBoff - Skeletal Health and Osteoporosis Center and Bone Density Unit, Brigham and Women's Hospital, Boston, MA
I Granek - Department of Preventive Medicine, Stony Brook University, Stony Brook, NY
D Bowen - Department of Social and Behavioral Sciences, Boston University School of Public Health, Boston, MA
L. G Snetselaar - Department of Epidemiology, University of Iowa College of Public Health, Iowa City
S. A Shumaker - Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC
J Ockene - UMMC Division of Preventive and Behavioral Medicine, University of Massachusetts, Worcester
M Rosal - UMMC Division of Preventive and Behavioral Medicine, University of Massachusetts, Worcester
J Wactawski-Wende - Department of Social and Preventive Medicine, State University of New York, Buffalo
J Cauley - Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA
B Cochrane - Family and Child Nursing Department, University of Washington, Seattle
L Tinker - Women's Health Initiative, Fred Hutchinson Cancer Research Center, Seattle, WA
R Jackson - Division of Endocrinology, Diabetes, and Metabolism, Ohio State University College of Medicine, Columbus
C. Y Wang - Fred Hutch Cancer Center
L Wu - Fred Hutch Cancer Center
Resource Type: Journal article
Publication Details: Behavioral Medicine, Vol.34(4), pp.145-155
DOI: 10.3200/BMED.34.4.145-155
PMID: 19064373
PMCID: PMC3770154
NLM abbreviation: Behav Med
ISSN: 0896-4289
eISSN: 1940-4026
Publisher: Heldref
Language: English
Date published: 01/01/2009
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9983995108102771

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