Journal article
Predictors of Pancreatic Cancer-Associated Weight Loss and Nutritional Interventions
Pancreas, Vol.46(9), pp.1152-1157
10/01/2017
DOI: 10.1097/MPA.0000000000000898
PMCID: PMC5679236
PMID: 28902785
Abstract
Objectives: Pancreatic ductal adenocarcinoma (PDAC) is often accompanied by weight loss. We sought to characterize factors associated with weight loss and observed nutritional interventions, as well as define the effect of weight loss on survival.
Methods: Consecutive subjects diagnosed with PDAC (N = 123) were retrospectively evaluated. Univariate analysis was used to compare subjects with and without substantial (> 5%) weight loss. Multivariate logistic regression was performed to identify factors associated with weight loss, and survival analyses were performed using Kaplan-Meier curves and Cox survival models.
Results: Substantial weight loss at diagnosis was present in 71.5% of subjects and was independently associated with higher baseline body mass index, longer symptom duration, and increased tumor size. Recommendations for nutrition consultation and pancreatic enzyme replacement therapy occurred in 27.6% and 36.9% of subjects, respectively. Weight loss (> 5%) was not associated with worse survival on multivariate analysis (hazard ratio, 1.32; 95% confidence interval, 0.76-2.30), unless a higher threshold (> 10%) was used (hazard ratio, 1.77; 95% confidence interval, 1.09-2.87).
Conclusions: Despite the high prevalence of weight loss at PDAC diagnosis, there are low observed rates of nutritional interventions. Weight loss based on current criteria for cancer cachexia is not associated with poor survival in PDAC.
Details
- Title: Subtitle
- Predictors of Pancreatic Cancer-Associated Weight Loss and Nutritional Interventions
- Creators
- Laura Nemer - The Ohio State University Wexner Medical CenterSomashekar G. Krishna - Mayo ClinicZarine K. Shah - The Ohio State UniversityDarwin L. Conwell - The Ohio State UniversityZobeida Cruz-Monserrate - The Ohio State UniversityMary Dillhoff - The Ohio State UniversityDenis C. Guttridge - The Ohio State UniversityAlice Hinton - The Ohio State UniversityAndrei Manilchuk - The Ohio State UniversityTimothy M. Pawlik - The Ohio State UniversityCarl R. Schmidt - The Ohio State UniversityErin E. Talbert - The Ohio State UniversityTanios Bekaii-Saab - Hematology/OncologyPhil A. Hart - The Ohio State University
- Resource Type
- Journal article
- Publication Details
- Pancreas, Vol.46(9), pp.1152-1157
- DOI
- 10.1097/MPA.0000000000000898
- PMID
- 28902785
- PMCID
- PMC5679236
- NLM abbreviation
- Pancreas
- ISSN
- 0885-3177
- eISSN
- 1536-4828
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 6
- Grant note
- U01DK108327 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) P30CA016058 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) U01DK108327 / National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases
- Language
- English
- Date published
- 10/01/2017
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984259642102771
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