Journal article
Predictors of electrocardiographic screening failure for the subcutaneous implantable cardioverter-defibrillator in children: A prospective multicenter study
Heart rhythm, Vol.15(5), pp.703-707
05/2018
DOI: 10.1016/j.hrthm.2018.01.004
PMID: 29309839
Abstract
Subcutaneous implantable cardioverter-defibrillator (SICD) shows promise for select patients at risk of sudden cardiac death. However, patients need to pass an electrocardiographic (ECG) screening (ECG-S) test before they can receive an SICD. Predictors of ECG-S failure in children are unclear.
The purpose of this study was to identify the incidence and predictive factors for failure of ECG-S in children.
Patients 18 years and younger with a preexisting ICD underwent ECG-S for SICD. ECG and demographic data were analyzed for factors predictive of failure.
Seventy-three patients (mean age 14.2 ± 3.3 years; range 5–18 years) with hypertrophic cardiomyopathy (n = 24, 33%), long QT syndrome (n =18, 25%), other inherited arrhythmia syndromes (n = 20, 27%), congenital heart disease (n = 9, 12%), and miscellaneous conditions (n = 2) with an existing transvenous ICD underwent prospective ECG-S. Nineteen (26%) failed ECG-S. Failed patients had a longer corrected QT (QTc) interval (457 ms vs 425 ms; P = .03), a longer QRS duration (120 ms vs 98 ms; P = .04), and a lower ratio of R-wave to T-wave amplitudes (R:T ratio) in lead aVF (4 vs 5; P = .001). Multivariable logistic regression identified QTc interval (odds ratio [OR] 4.31; P = .04), QRS duration (OR 4.93; P = .03), R:T ratio in lead aVF (OR 3.13; P = .08) as predictors of failure. A risk score with 1 point each for QTc interval >440 ms, QRS duration >120 ms, and R:T ratio <6.5 in lead aVF was associated with probability of failure of 15.4% (1 point), 47.4% (2 points), and 88.6% (3 points), respectively.
ECG-S failure for SICD occurred in 26% of children, which is higher than the reported incidence in adults. Factors predicting ECG-S failure included longer QTc interval, longer QRS duration, and lower R:T ratio in lead aVF.
Details
- Title: Subtitle
- Predictors of electrocardiographic screening failure for the subcutaneous implantable cardioverter-defibrillator in children: A prospective multicenter study
- Creators
- Matthew Campbell - Oregon Health and Science University, Portland, OregonJeremy P Moore - University of California, Los Angeles, Los Angeles, CaliforniaNarayanswami Sreeram - University Hospital of Cologne, Cologne, GermanyJohannes C von Alvensleben - Children's Hospital Colorado, University of Colorado, Aurora, ColoradoAnjan Shah - University of Oklahoma, Oklahoma City, OklahomaAnjan Batra - University of California, Irvine, Orange, CaliforniaIan Law - University of Iowa, Iowa City, IowaShubhayan Sanatani - University of British Columbia, Vancouver, British Columbia, CanadaVincent Thomas - University of Nebraska, Omaha, NebraskaFarnoosh Nik-Ahd - University of California, Los Angeles, Los Angeles, CaliforniaStephen Williams - University of Oklahoma Medical CenterNina Nosavan - University of California, Irvine, Orange, CaliforniaJennifer Maldonado - University of Iowa, Iowa City, IowaAmelia Hart - University of British Columbia, Vancouver, British Columbia, CanadaThuan Nguyen - Oregon Health and Science University, Portland, OregonSeshadri Balaji - Oregon Health and Science University, Portland, Oregon
- Resource Type
- Journal article
- Publication Details
- Heart rhythm, Vol.15(5), pp.703-707
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.hrthm.2018.01.004
- PMID
- 29309839
- ISSN
- 1547-5271
- eISSN
- 1556-3871
- Language
- English
- Date published
- 05/2018
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984093357002771
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