Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry

Antonia Sambola; Jordi Lozano-Torres; Eric Boersma; Carmen Olmos; Julien Ternacle; Francisco Calvo; Christophe Tribouilloy; Vlatka Reskovic-Luksic; Jadranka Separovic-Hanzevacki; Seung-Woo Park; Sebastiaan Bekkers; Kwan-Leung Chan; Abdallah Almaghraby; Bernard Iung; Patrizio Lancellotti; Gilbert Habib; European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry Investigator Group; Y Saleh

doi:10.1093/eurheartj/ehad507

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Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry

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Peer reviewed

Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry

Antonia Sambola, Jordi Lozano-Torres, Eric Boersma, Carmen Olmos, Julien Ternacle, Francisco Calvo, Christophe Tribouilloy, Vlatka Reskovic-Luksic, Jadranka Separovic-Hanzevacki, Seung-Woo Park, …

European Heart Journal, Vol.44(43), pp.4566-4575

08/18/2023

DOI: 10.1093/eurheartj/ehad507

PMID: 37592753

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Abstract

Background and Aims Even though vegetation size in infective endocarditis (IE) has been associated with embolic events (EEs) and mortality risk, it is unclear whether vegetation size associated with these potential outcomes is different in left-sided IE (LSIE). This study aimed to seek assessing the vegetation cut-off size as predictor of EE or 30-day mortality for LSIE and to determine risk predictors of these outcomes. Methods The European Society of Cardiology EURObservational Research Programme European Infective Endocarditis is a prospective, multicentre registry including patients with definite or possible IE throughout 2016–18. Cox multivariable logistic regression analysis was performed to assess variables associated with EE or 30-day mortality. Results There were 2171 patients with LSIE (women 31.5%). Among these affected patients, 459 (21.1%) had a new EE or died in 30 days. The cut-off value of vegetation size for predicting EEs or 30-day mortality was >10 mm [hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.13–1.69, P = .0015]. Other adjusted predictors of risk of EE or death were as follows: EE on admission (HR 1.89, 95% CI 1.54–2.33, P < .0001), history of heart failure (HR 1.53, 95% CI 1.21–1.93, P = .0004), creatinine >2 mg/dL (HR 1.59, 95% CI 1.25–2.03, P = .0002), Staphylococcus aureus (HR 1.36, 95% CI 1.08–1.70, P = .008), congestive heart failure (HR 1.40, 95% CI 1.12–1.75, P = .003), presence of haemorrhagic stroke (HR 4.57, 95% CI 3.08–6.79, P < .0001), alcohol abuse (HR 1.45, 95% CI 1.04–2.03, P = .03), presence of cardiogenic shock (HR 2.07, 95% CI 1.29–3.34, P = .003), and not performing left surgery (HR 1.30 95% CI 1.05–1.61, P = .016) (C-statistic = .68). Conclusions Prognosis after LSIE is determined by multiple factors, including vegetation size.

Cardiology

Registries

10209 Clinic for Cardiology

2705 Cardiology and Cardiovascular Medicine

610 Medicine & health

[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

Embolic events

Embolism

Endocarditis

Endocarditis, Bacterial

Female

Humans

Infective endocarditis

Left-sided infective endocarditis

Mortality

Prospective Studies

Retrospective Studies

Risk Factors

Vegetation size

Details

Title: Subtitle: Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry
Creators: Antonia Sambola - Vall d'Hebron Hospital Universitari
Jordi Lozano-Torres - Vall d'Hebron Hospital Universitari
Eric Boersma - Erasmus MC
Carmen Olmos - Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
Julien Ternacle - Hôpitaux Universitaires Henri-Mondor
Francisco Calvo
Christophe Tribouilloy - Université de Picardie Jules Verne
Vlatka Reskovic-Luksic - University Hospital Centre Zagreb
Jadranka Separovic-Hanzevacki - University Hospital Centre Zagreb
Seung-Woo Park - Samsung Medical Center
Sebastiaan Bekkers - Maastricht University Medical Centre
Kwan-Leung Chan - University of Ottawa
Abdallah Almaghraby - Alexandria University
Bernard Iung - Université Paris Cité
Patrizio Lancellotti - Centre Hospitalier Universitaire de Liège
Gilbert Habib - Hôpital de la Timone
European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry Investigator Group
Y Saleh (Contributor)
Resource Type: Journal article
Publication Details: European Heart Journal, Vol.44(43), pp.4566-4575
Publisher: Oxford University Press (OUP); OXFORD
DOI: 10.1093/eurheartj/ehad507
PMID: 37592753
ISSN: 0195-668X
eISSN: 1522-9645
Grant note: Abbott Vascular Int.: 201121 Amgen CardiovascularAstraZenecaBristol Myers SquibbPfizer AllianceDaiichi Sankyo Europe GmbHAlliance Daiichi Sankyo Europe GmbHEdwardsGedeon Richter Plc.MSD-Merck amp; CoNovartis Pharma AGResMedSERVIERSanofiVifor
This work was supported by Abbott Vascular Int. (2011-21), Amgen Cardiovascular (2009-18), AstraZeneca (2014-21), Bayer AG (2009- 18), Boehringer Ingelheim (2009-19), Boston Scientific (2009-12), The Bristol Myers Squibb and Pfizer Alliance (2011-19), Daiichi Sankyo Europe GmbH (2011-20), The Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company (2014-17), Edwards (2016-19), Gedeon Richter Plc. (2014-16), Menarini Int. Op. (2009- 12), MSD-Merck & Co. (2011-14), Novartis Pharma AG (2014-20), ResMed (2014-16), Sanofi (2009-11), SERVIER (2009-21), and Vifor (2019-22).
Language: Japanese
Date published: 08/18/2023
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984802405802771

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