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Predictors of post-operative pancreatic fistula formation in pancreatic neuroendocrine tumors: A national surgical quality improvement program analysis
Journal article   Open access   Peer reviewed

Predictors of post-operative pancreatic fistula formation in pancreatic neuroendocrine tumors: A national surgical quality improvement program analysis

Elizabeth A. Hedges, Tahsin M. Khan, Bruna Babic and Naris Nilubol
The American journal of surgery, Vol.224(5), pp.1256-1261
11/01/2022
DOI: 10.1016/j.amjsurg.2022.07.007
PMCID: PMC9700260
PMID: 35999087
url
https://doi.org/10.1016/j.amjsurg.2022.07.007View
Published (Version of record) Open Access

Abstract

Background: Post-operative pancreatic fistula (POPF) is a serious complication following pancreas surgery. We aimed to establish factors associated with POPF specifically in patients with pancreatic neuroendocrine tumors (PNET). Methods: The 2014-2018 American College of Surgeons National Surgical Quality Improvement Program database was querried for patients undergoing resection for PNET. The impact of patient, tumor, and operative factors on POPF formation was evaluated. Results: 3532 patient underwent resections for PNET. The POPF rate was significantly higher in patients with PNET (24.8%) versus non-PNET (16.4%) (p < 0.0001). Male sex (OR 1.45, 95% CI 1.11-1.89), enucleation (OR 3.14, 95% CI 1.10-8.98), pancreaticoduodenectomy (OR 1.51, 95% CI 1.13-2.03), small duct size <3 mm (OR 3.24, 95% CI 1.62-6.48), and soft gland texture (OR 1.81, 95% CI 1.18-2.77) were independently associated with POPF in PNET patients on multivariable analysis. Conclusions: POPF is more common in patients undergoing resection for PNET and is dictated primarily by surgical approach and gland characteristics.
 Life Sciences & Biomedicine Science & Technology Surgery

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