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Predictors of response to alprazolam and placebo in patients with panic disorder
Journal article   Peer reviewed

Predictors of response to alprazolam and placebo in patients with panic disorder

Catherine L Woodman, Russell Noyes, James C Ballenger, R.Bruce Lydiard, Gerald Sievers and Daniel Mihalko
Journal of affective disorders, Vol.30(1), pp.5-13
01/1994
DOI: 10.1016/0165-0327(94)90146-5
PMID: 8151049

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Abstract

Date from a panic disorder treatment study with 506 patients, comparing alprazolam and placebo in a double-blind manner for 8 weeks, were analyzed to identify demographic and clinical characteristics of the patients that might predict response to treatment. The strongest predictors of response to alprazolam were age over 40, and lower baseline levels of anxiety and phobic symptoms. Predictors of response to placebo were weaker and, in addition to lower levels anxiety and panic attacks, included a lack of previous psychiatric treatment.

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