Journal article
Prefrontal-Bed Nucleus Circuit Modulation of a Passive Coping Response Set
The Journal of neuroscience, Vol.39(8), pp.1405-1419
02/20/2019
DOI: 10.1523/jneurosci.1421-18.2018
PMCID: PMC6381256
PMID: 30573644
Abstract
One of the challenges facing neuroscience entails localization of circuits and mechanisms accounting for how multiple features of stress responses are organized to promote survival during adverse experiences. The rodent medial prefrontal cortex (mPFC) is generally regarded as a key site for cognitive and affective information processing, and the anteroventral bed nuclei of the stria terminalis (avBST) integrates homeostatic information from a variety of sources, including the mPFC. Thus, we proposed that the mPFC is capable of generating multiple features (endocrine, behavioral) of adaptive responses via its influence over the avBST. To address this possibility, we first optogenetically inhibited input to avBST from the rostral prelimbic cortical region of mPFC and observed concurrent increases in immobility and hypothalamo-pituitary-adrenal (HPA) output in male rats during tail suspension, whereas photostimulation of this pathway decreased immobility during the same challenge. Anatomical tracing experiments confirmed projections from the rostral prelimbic subfield to separate populations of avBST neurons, and from these to HPA effector neurons in the paraventricular hypothalamic nucleus, and to aspects of the midbrain periaqueductal gray that coordinate passive defensive behaviors. Finally, stimulation and inhibition of the prelimbic-avBST pathway, respectively, decreased and increased passive coping in the shock-probe defensive burying test, without having any direct effect on active coping (burying) behavior. These results define a new neural substrate in the coordination of a
that involves the gating of passive, rather than active, coping behaviors while restraining neuroendocrine activation to optimize adaptation during threat exposure.
The circuits and mechanisms accounting for how multiple features of responses are organized to promote adaptation have yet to be elucidated. Our report identifies a prefrontal-bed nucleus pathway that organizes a
capable of gating passive coping behaviors while concurrently restraining neuroendocrine activation during exposure to inescapable stressors. These data provide insight into the central organization of how multiple features of responses are integrated to promote adaptation during adverse experiences, and how disruption in one neural pathway may underlie a broad array of maladaptive responses in stress-related psychiatric disorders.
Details
- Title: Subtitle
- Prefrontal-Bed Nucleus Circuit Modulation of a Passive Coping Response Set
- Creators
- Shane B Johnson - Interdisciplinary Neuroscience ProgramEric B Emmons - Interdisciplinary Neuroscience ProgramRyan T Lingg - Department of Psychological and Brain SciencesRachel M Anderson - Department of Psychological and Brain SciencesSara A Romig-Martin - Department of Psychological and Brain SciencesRyan T LaLumiere - Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242, andNandakumar S Narayanan - Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242, andVictor Viau - Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, CanadaJason J Radley - Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa 52242, and
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.39(8), pp.1405-1419
- Publisher
- United States
- DOI
- 10.1523/jneurosci.1421-18.2018
- PMID
- 30573644
- PMCID
- PMC6381256
- ISSN
- 1529-2401
- eISSN
- 1529-2401
- Grant note
- R56 MH095972 / NIMH NIH HHS R01 MH095972 / NIMH NIH HHS R01 MH116043 / NIMH NIH HHS
- Language
- English
- Date published
- 02/20/2019
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002372702771
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