Journal article
Prefrontal D1 Dopamine-Receptor Neurons and Delta Resonance in Interval Timing
Cerebral cortex (New York, N.Y. 1991), Vol.29(5), pp.2051-2060
05/2019
DOI: 10.1093/cercor/bhy083
PMCID: PMC6458904
PMID: 29897417
Abstract
Considerable evidence has shown that prefrontal neurons expressing D1-type dopamine receptors (D1DRs) are critical for working memory, flexibility, and timing. This line of work predicts that frontal neurons expressing D1DRs mediate cognitive processing. During timing tasks, one form this cognitive processing might take is time-dependent ramping activity—monotonic changes in firing rate over time. Thus, we hypothesized the prefrontal D1DR+ neurons would strongly exhibit time-dependent ramping during interval timing. We tested this idea using an interval-timing task in which we used optogenetics to tag D1DR+ neurons in the mouse medial frontal cortex (MFC). While 23% of MFC D1DR+ neurons exhibited ramping, this was significantly less than untagged MFC neurons. By contrast, MFC D1DR+ neurons had strong delta-frequency (1–4 Hz) coherence with other MFC ramping neurons. This coherence was phase-locked to cue onset and was strongest early in the interval. To test the significance of these interactions, we optogenetically stimulated MFC D1DR+ neurons early versus late in the interval. We found that 2-Hz stimulation early in the interval was particularly effective in rescuing timing-related behavioral performance deficits in dopamine-depleted animals. These findings provide insight into MFC networks and have relevance for disorders such as Parkinson’s disease and schizophrenia.
Details
- Title: Subtitle
- Prefrontal D1 Dopamine-Receptor Neurons and Delta Resonance in Interval Timing
- Creators
- Young-Cho Kim - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USANandakumar S Narayanan - Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Cerebral cortex (New York, N.Y. 1991), Vol.29(5), pp.2051-2060
- Publisher
- Oxford University Press
- DOI
- 10.1093/cercor/bhy083
- PMID
- 29897417
- PMCID
- PMC6458904
- ISSN
- 1047-3211
- eISSN
- 1460-2199
- Grant note
- 2014/22817-1 / ; ; R01NS078100/K08 NS078100 / ; ; ;
- Language
- English
- Date published
- 05/2019
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984070684102771
Metrics
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