Journal article
Prefrontal cortex supports speech perception in listeners with cochlear implants
eLife, Vol.11, 75323
06/06/2022
DOI: 10.7554/eLife.75323
PMCID: PMC9225001
PMID: 35666138
Abstract
Cochlear implants are neuroprosthetic devices that can restore hearing in people with severe to profound hearing loss by electrically stimulating the auditory nerve. Because of physical limitations on the precision of this stimulation, the acoustic information delivered by a cochlear implant does not convey the same level of acoustic detail as that conveyed by normal hearing. As a result, speech understanding in listeners with cochlear implants is typically poorer and more effortful than in listeners with normal hearing. The brain networks supporting speech understanding in listeners with cochlear implants are not well understood, partly due to difficulties obtaining functional neuroimaging data in this population. In the current study, we assessed the brain regions supporting spoken word understanding in adult listeners with right unilateral cochlear implants (n=20) and matched controls (n=18) using high-density diffuse optical tomography (HD-DOT), a quiet and non-invasive imaging modality with spatial resolution comparable to that of functional MRI. We found that while listening to spoken words in quiet, listeners with cochlear implants showed greater activity in the left prefrontal cortex than listeners with normal hearing, specifically in a region engaged in a separate spatial working memory task. These results suggest that listeners with cochlear implants require greater cognitive processing during speech understanding than listeners with normal hearing, supported by compensatory recruitment of the left prefrontal cortex.
Details
- Title: Subtitle
- Prefrontal cortex supports speech perception in listeners with cochlear implants
- Creators
- Arefeh Sherafati - Washington University in St. LouisNoel Dwyer - Washington University in St. LouisAahana Bajracharya - Washington University in St. LouisMahlega Samira Hassanpour - University of UtahAdam T. Eggebrecht - Washington University in St. LouisJill B. Firszt - Washington University in St. LouisJoseph P. Culver - Washington University in St. LouisJonathan E. Peelle - Washington University in St. LouisTimothy D. Griffiths
- Resource Type
- Journal article
- Publication Details
- eLife, Vol.11, 75323
- Publisher
- eLIFE SCIENCES PUBL LTD
- DOI
- 10.7554/eLife.75323
- PMID
- 35666138
- PMCID
- PMC9225001
- ISSN
- 2050-084X
- eISSN
- 2050-084X
- Number of pages
- 23
- Grant note
- R21DC015884; R21DC016086; K01MH103594; R21MH109775; R01NS090874; R01NS109487; R01DC019507 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 06/06/2022
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984632145802771
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