Journal article
Prefrontal dopamine signaling and cognitive symptoms of Parkinson’s Disease
Reviews in the neurosciences, Vol.24(3), pp.267-278
2013
DOI: 10.1515/revneuro-2013-0004
PMCID: PMC3836593
PMID: 23729617
Abstract
Cognitive dysfunction is a common symptom of Parkinson’s disease that causes significant morbidity and mortality. The severity of these symptoms ranges from minor executive symptoms to frank dementia involving multiple domains. In the present review, we will concentrate on the aspects of cognitive impairment associated with prefrontal dopaminergic dysfunction seen in non-demented patients with PD. These symptoms include executive dysfunction and disorders of thought such as hallucinations and psychosis. Such symptoms may go on to predict dementia related to Parkinson’s disease, which involves amnestic dysfunction and is typically seen later in the disease. Cognitive symptoms are associated with dysfunction in cholinergic circuits in addition to the abnormalities in the prefrontal dopaminergic system. These circuits can be carefully studied and evaluated in Parkinson’s disease, and could be leveraged to treat difficult clinical problems related to cognitive symptoms of PD.
Details
- Title: Subtitle
- Prefrontal dopamine signaling and cognitive symptoms of Parkinson’s Disease
- Creators
- Nandakumar S Narayanan - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IARobert L Rodnitzky - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IAErgun Uc - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Reviews in the neurosciences, Vol.24(3), pp.267-278
- DOI
- 10.1515/revneuro-2013-0004
- PMID
- 23729617
- PMCID
- PMC3836593
- NLM abbreviation
- Rev Neurosci
- ISSN
- 0334-1763
- eISSN
- 2191-0200
- Grant note
- K08 NS078100 || NS / National Institute of Neurological Disorders and Stroke : NINDS
- Language
- English
- Date published
- 2013
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984020608202771
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