Pregnancy Complications and the Risk of Metabolic Syndrome for the Offspring

Kelli K Ryckman; Kristi S Borowski; Nisha I Parikh; Audrey F Saftlas

doi:10.1007/s12170-013-0308-y

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Pregnancy Complications and the Risk of Metabolic Syndrome for the Offspring

Journal article

Peer reviewed

Pregnancy Complications and the Risk of Metabolic Syndrome for the Offspring

Kelli K Ryckman, Kristi S Borowski, Nisha I Parikh and Audrey F Saftlas

Current cardiovascular risk reports, Vol.7(3), pp.217-223

06/2013

DOI: 10.1007/s12170-013-0308-y

PMCID: PMC3755758

PMID: 23997844

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https://www.ncbi.nlm.nih.gov/pmc/articles/3755758View

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Abstract

Metabolic syndrome is a growing problem globally, and is a contributor to non-communicable diseases such as type II diabetes and cardiovascular disease. The risk of developing specific components of the metabolic syndrome such as obesity, hyperlipidemia, hypertension, and elevated fasting blood sugar has been largely attributed to environmental stressors including poor nutrition, lack of exercise, and smoking. However, large epidemiologic cohorts and experimental animal models support the “developmental origins of adult disease” hypothesis, which posits that a significant portion of the risk for adult metabolic conditions is determined by exposures occurring in the perinatal period. Maternal obesity and the rate of complications during pregnancy such as preterm birth, preeclampsia, and gestational diabetes continue to rise. As our ability to reduce perinatal morbidity and mortality improves the long-term metabolic consequences remain uncertain, pointing to the need for further research in this area.

Cardiovascular disease

Gestational diabetes

Hyperlipidemia

Hypertension

Maternal obesity

Metabolic syndrome

Preeclampsia

Pregnancy complications

Type II diabetes

Details

Title: Subtitle: Pregnancy Complications and the Risk of Metabolic Syndrome for the Offspring
Creators: Kelli K Ryckman - Department of Epidemiology, University of Iowa, 105 River St, Iowa City, IA 52242, USA
Kristi S Borowski - Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA
Nisha I Parikh - Cardiovascular Division, The Queens Medical Center, Honolulu, HI 96813, USA
Audrey F Saftlas - Department of Epidemiology, University of Iowa, 105 River St, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: Current cardiovascular risk reports, Vol.7(3), pp.217-223
DOI: 10.1007/s12170-013-0308-y
PMID: 23997844
PMCID: PMC3755758
NLM abbreviation: Curr Cardiovasc Risk Rep
ISSN: 1932-9520
eISSN: 1932-9563
Grant note: K99 HD065786 || HD / National Institute of Child Health & Human Development : NICHD
Language: English
Date published: 06/2013
Academic Unit: Stead Family Department of Pediatrics; Epidemiology
Record Identifier: 9984214792102771

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