Pregnancy-Related Changes of Amino Acid and Acylcarnitine Concentrations: The Impact of Obesity

Kelli K Ryckman; Brittney M Donovan; Diedre K Fleener; Bruce Bedell; Kristi S Borowski

doi:10.1055/s-0036-1592414

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Pregnancy-Related Changes of Amino Acid and Acylcarnitine Concentrations: The Impact of Obesity

Journal article

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Pregnancy-Related Changes of Amino Acid and Acylcarnitine Concentrations: The Impact of Obesity

Kelli K Ryckman, Brittney M Donovan, Diedre K Fleener, Bruce Bedell and Kristi S Borowski

American journal of perinatology reports, Vol.6(3), pp.e329-e336

07/2016

DOI: 10.1055/s-0036-1592414

PMCID: PMC5031496

PMID: 27672481

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Abstract

Objective Our primary objective was to assess the difference in amino and fatty acid biomarkers throughout pregnancy in women with and without obesity. Interactions between biomarkers and obesity status for associations with maternal and fetal metabolic measures were secondarily analyzed. Methods Overall 39 women (15 cases, 24 controls) were enrolled in this study during their 15- to 20-weeks' visit at the University of Iowa Hospitals and Clinics. We analyzed 32 amino acid and acylcarnitine concentrations with tandem mass spectrometry for differences throughout pregnancy as well as among women with and without obesity (body mass index [BMI] ≥ 35, BMI < 25). Results There were substantial changes in amino acids and acylcarnitine metabolites between the second and third trimesters (nonfasting state) of pregnancy that were significant after correcting for multiple testing ( p < 0.002). Examining differences by maternal obesity, C8:1 (second trimester) and C2, C4-OH, C18:1 (third trimester) were higher in women with obesity compared with women without obesity. Several metabolites were marginally (0.002 < p < 0.05) correlated with birth weight, maternal glucose, and maternal weight gain stratified by obesity status and trimester. Conclusions Understanding maternal metabolism throughout pregnancy and the influence of obesity is a critical step in identifying potential mechanisms that may contribute to adverse outcomes in pregnancies complicated by obesity.

fatty acids

maternal obesity

amino acids

pregnancy

longitudinal

acylcarnitines

Case Report

Details

Title: Subtitle: Pregnancy-Related Changes of Amino Acid and Acylcarnitine Concentrations: The Impact of Obesity
Creators: Kelli K Ryckman - Department of Epidemiology, University of Iowa, Iowa City, Iowa
Brittney M Donovan - Department of Epidemiology, University of Iowa, Iowa City, Iowa
Diedre K Fleener - Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa
Bruce Bedell - Department of Pediatrics, University of Iowa, Iowa City, Iowa
Kristi S Borowski - Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota
Resource Type: Journal article
Publication Details: American journal of perinatology reports, Vol.6(3), pp.e329-e336
DOI: 10.1055/s-0036-1592414
PMID: 27672481
PMCID: PMC5031496
NLM abbreviation: AJP Rep
ISSN: 2157-6998
eISSN: 2157-7005
Publisher: Thieme Medical Publishers; 333 Seventh Avenue, New York, NY 10001, USA
Language: English
Date published: 07/2016
Academic Unit: Stead Family Department of Pediatrics; Epidemiology
Record Identifier: 9983995167502771

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