Pregnancy and Long-Term Postnatal Outcomes of Congenital Sacrococcygeal Teratoma: A Single Institution's 18-Year Experience

Ava D Mandelbaum; Raphael C Sun; Amanda J H Kim; Roya Sohaey; Melanie Hakar; Saharnaz Tavoosi; Lucy Ward; Monica Rincon; Allison J Allen; Stephanie Dukhovny; Andrew H Chon

doi:10.1002/bdr2.2405

Back

Pregnancy and Long-Term Postnatal Outcomes of Congenital Sacrococcygeal Teratoma: A Single Institution's 18-Year Experience

Journal article

Peer reviewed

Pregnancy and Long-Term Postnatal Outcomes of Congenital Sacrococcygeal Teratoma: A Single Institution's 18-Year Experience

Ava D Mandelbaum, Raphael C Sun, Amanda J H Kim, Roya Sohaey, Melanie Hakar, Saharnaz Tavoosi, Lucy Ward, Monica Rincon, Allison J Allen, Stephanie Dukhovny, …

Birth defects research, Vol.116(10), pp.e2405-n/a

10/2024

DOI: 10.1002/bdr2.2405

PMID: 39425502

View Online

Abstract

The objective of this study is to evaluate outcomes of fetal sacrococcygeal teratoma (SCT) from an academic tertiary center. This is a retrospective study evaluating pregnancy and postnatal outcomes of fetal SCT management at a single institution between 2006 and 2023. Results are reported as median (range). Fourteen patients with fetal SCT were studied. Hydrops fetalis occurred in 2 (14.3%) cases. Pregnancy course included expectant management in 12 (85.7%) and palliative preterm induction in 1 patient (7.1%). Indications for delivering timing included fetal deterioration in 7 patients (50%), preeclampsia in 3 (21.4%), elective induction of delivery in 3 (21.4%), and preterm labor in 1 (7.1%). Delivery GA was 36.4 weeks (26.4-40.1 weeks), with 11 (78.5%) cesareans and 3 (21.4%) vaginal deliveries. There were 13 (92.9%) live births and 11 (78.6%) long-term survivors. Postnatal resection pathology demonstrated 7 (53.8%) mature, 3 (23.1%) immature, and 3 (23.1%) malignant SCTs. Of the 11 long-term survivors, 3 (27.3%) had teratoma recurrences, including 2 (18.2%) with metastatic disease requiring chemotherapy. Notable long-term complications involved gastrointestinal (n = 7, 63.6%), genitourinary (n = 4, 36.4%), and musculoskeletal (n = 2, 18.2%) systems. SCT confers significant morbidity to both the pregnant patient and neonate. Multidisciplinary prenatal and postnatal care is needed to comprehensively manage this complex condition.

Adult

Female

Humans

Hydrops Fetalis

Infant, Newborn

Male

Pregnancy

Pregnancy Outcome

Retrospective Studies

Sacrococcygeal Region - abnormalities

Teratoma

Details

Title: Subtitle: Pregnancy and Long-Term Postnatal Outcomes of Congenital Sacrococcygeal Teratoma: A Single Institution's 18-Year Experience
Creators: Ava D Mandelbaum - Oregon Health & Science University
Raphael C Sun - Oregon Health & Science University
Amanda J H Kim - Oregon Health & Science University
Roya Sohaey - Oregon Health & Science University
Melanie Hakar - Oregon Health & Science University
Saharnaz Tavoosi - Eurofins Laboratories, Des Moines, Iowa, USA
Lucy Ward - Oregon Health & Science University
Monica Rincon - Oregon Health & Science University
Allison J Allen - Oregon Health & Science University
Stephanie Dukhovny - Oregon Health & Science University
Andrew H Chon - Oregon Health & Science University
Resource Type: Journal article
Publication Details: Birth defects research, Vol.116(10), pp.e2405-n/a
DOI: 10.1002/bdr2.2405
PMID: 39425502
NLM abbreviation: Birth Defects Res
ISSN: 2472-1727
eISSN: 2472-1727
Publisher: Wiley
Language: English
Date published: 10/2024
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9984848501602771

Metrics

12 Record Views