Journal article
Pregnancy outcomes in women with type 1 diabetes in China during 2004 to 2014: A retrospective study (the CARNATION Study)
Journal of diabetes, Vol.14(1), pp.5-14
01/01/2022
DOI: 10.1111/1753-0407.13229
PMCID: PMC9060029
PMID: 34617682
Abstract
Background We aimed to report pregnancy outcomes of women with type 1 diabetes (T1D) in China, on which data were sparse. Methods This is a nationwide retrospective study conducted in 11 general medical centers in 8 cities across China. We investigated the clinical data of all women who attended these centers with a singleton pregnancy and whose pregnancy ended between 1 January 2004 and 31 December 2014. Pregnancies of women with pregestational T1D were ascertained and compared with those of women without T1D. Results From over 300 000 pregnancies over the 11-year study period, we identified 265 singleton pregnancies of women with T1D. One maternal death was documented among 265 (0.37%) women with T1D and 83 among 318 486 (0.03%) women without T1D. Women with T1D suffered from higher rates of pregnancy loss (13.21% vs 2.92%, crude risk ratio [cRR] 5.08 [95% CI, 3.56-7.26]) and preeclampsia (17.74% vs 4.20%, cRR 4.94 [95% CI, 3.60-6.77]) compared with those without T1D. Infants of these women with T1D had elevated rates of neonatal death (5.65% vs 0.16%, cRR 37.36 [95% CI, 21.21-65.82]) and congenital malformation(s) (8.26% vs 3.53%, cRR 2.46 [95% CI, 1.54-3.93]) compared with those of women without T1D. No significant improvement in pregnancy outcomes in women with T1D was observed over the period 2004 to 2014. Conclusions Pregnancy outcomes were persistently poor in women with T1D during 2004 to 2014 in China. Pregnancy care needs to be improved to reduce adverse pregnancy outcomes among Chinese women with T1D.
Details
- Title: Subtitle
- Pregnancy outcomes in women with type 1 diabetes in China during 2004 to 2014: A retrospective study (the CARNATION Study)
- Creators
- Sihui Luo - University of Science and Technology of ChinaXingwu Ran - Sichuan UniversityMei Zhang - Jiangsu Province HospitalJi Hu - Second Affiliated Hospital of Soochow UniversityDaizhi Yang - Third Affiliated Hospital of Sun Yat-sen UniversityDalong Zhu - Nanjing Drum Tower HospitalJiajun Zhao - Shandong UniversityXinhua Xiao - Peking Union Medical College HospitalXiaohui Guo - Peking University First HospitalTao Yang - Jiangsu Province HospitalQin Huang - Second Military Medical UniversityFang Liu - Shanghai Sixth People's HospitalLu Jing - Nanjing Drum Tower HospitalJing Ma - Sichuan UniversityXinli Zhou - Shandong Provincial HospitalFan Ping - Peking Union Medical College HospitalNan Gu - Peking University First HospitalWenwen Li - Second Military Medical UniversityYaling Yang - Second Xiangya Hospital of Central South UniversityChen Fang - Second Affiliated Hospital of Soochow UniversityWei Bao - University of IowaXueying Zheng - University of Science and Technology of ChinaJinhua Yan - Sun Yat-sen UniversityZhiguang Zhou - Second Xiangya Hospital of Central South UniversityJianping Weng - Third Affiliated Hospital of Sun Yat-sen University
- Resource Type
- Journal article
- Publication Details
- Journal of diabetes, Vol.14(1), pp.5-14
- DOI
- 10.1111/1753-0407.13229
- PMID
- 34617682
- PMCID
- PMC9060029
- NLM abbreviation
- J Diabetes
- ISSN
- 1753-0393
- eISSN
- 1753-0407
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- 201502011 / Foundation for Public Welfare Industry Research National Health and Family Planning Commission of the People's Republic of China
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Epidemiology
- Record Identifier
- 9984364381502771
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