Journal article
Prehospital oral chlorhexidine does not reduce the rate of ventilator-associated pneumonia among critically ill trauma patients: A prospective concurrent-control study
Journal of critical care, Vol.30(4), pp.787-792
08/2015
DOI: 10.1016/j.jcrc.2015.03.017
PMID: 25964208
Abstract
The purpose of the study was to test the hypothesis that prehospital oral chlorhexidine administered to intubated trauma patients will decrease the Clinical Pulmonary Infection Score (CPIS) during the first 2 days of hospitalization.
Prospective interventional concurrent-control study of all intubated adult trauma patients transported by air ambulance to a 711-bed Midwestern academic trauma center over a 1-year period. Patients transported by 2 university-based helicopters were treated with oral chlorhexidine after intubation, and the control group was patients transported by other air transport services.
Sixty-seven patients were enrolled, of which 23 received chlorhexidine (9 patients allocated to the intervention were not treated). The change in CPIS score was no different between the intervention and control groups by intention to treat (1.06- vs 1.40-point reduction, P = .520), and no difference was observed in tracheal colonization (29.0% vs 36.7%, P = .586). No differences were observed in the rate of clinical pneumonia (8.7% vs 8.6%, P = .987) or mortality (P = .196) in the per-protocol chlorhexidine group.
The prehospital administration of oral chlorhexidine does not reduce the CPIS score over the first 48 hours of admission for intubated trauma patients. Further study should explore other prehospital strategies of reducing complications of critical illness.
Details
- Title: Subtitle
- Prehospital oral chlorhexidine does not reduce the rate of ventilator-associated pneumonia among critically ill trauma patients: A prospective concurrent-control study
- Creators
- Nicholas M Mohr - Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IACarlos A Pelaez Gil - Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IAKarisa K Harland - Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IABrett Faine - Department of Pharmaceutical Services, University of Iowa Hospitals and Clinics, Iowa City, IAAndrew Stoltze - Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IAKent Pearson - Division of Critical Care, Department of Anesthesia, University of Iowa Carver College of Medicine, Iowa City, IAAzeemuddin Ahmed - Department of Emergency Medicine, University of Iowa Carver College of Medicine, Iowa City, IA
- Resource Type
- Journal article
- Publication Details
- Journal of critical care, Vol.30(4), pp.787-792
- DOI
- 10.1016/j.jcrc.2015.03.017
- PMID
- 25964208
- NLM abbreviation
- J Crit Care
- ISSN
- 0883-9441
- eISSN
- 1557-8615
- Publisher
- Elsevier Inc
- Grant note
- name: Iowa Injury Prevention Research Center; DOI: 10.13039/100000030, name: Centers for Disease Control and Prevention, award: 1R49CE002108-01
- Language
- English
- Date published
- 08/2015
- Academic Unit
- Management and Entrepreneurship ; Epidemiology; Emergency Medicine; Surgery; Pharmacy Practice and Science; Center for Social Science Innovation; Anesthesia; Injury Prevention Research Center; Public Policy Center (Archive); Law Faculty
- Record Identifier
- 9984024523802771
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