Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons

Joseph M. Stujenske; Pia-Kelsey O'neill; Carolina Fernandes-Henriques; Itzick Nahmoud; Samantha R. Goldburg; Ashna Singh; Laritza Diaz; Margarita Labkovich; William Hardin; Scott S. Bolkan; Thomas R. Reardon; Timothy J. Spellman; C. Daniel Salzman; Joshua A. Gordon; Conor Liston; Ekaterina Likhtik

doi:10.1016/j.neuron.2022.03.020

Back

Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons

Journal article

Open access

Peer reviewed

Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons

Joseph M. Stujenske, Pia-Kelsey O'neill, Carolina Fernandes-Henriques, Itzick Nahmoud, Samantha R. Goldburg, Ashna Singh, Laritza Diaz, Margarita Labkovich, William Hardin, Scott S. Bolkan, …

Neuron (Cambridge, Mass.), Vol.110(14), pp.2258-2267.e11

07/20/2022

DOI: 10.1016/j.neuron.2022.03.020

PMCID: PMC9308671

PMID: 35397211

Files and links (1)

url

https://doi.org/10.1016/j.neuron.2022.03.020View

Published (Version of record) Open Access

Abstract

The amygdala and prelimbic cortex (PL) communicate during fear discrimination retrieval, but how they co-ordinate discrimination of a non-threatening stimulus is unknown. Here, we show that somatostatin (SOM) interneurons in the basolateral amygdala (BLA) become active specifically during learned non-threatening cues and desynchronize cell firing by blocking phase reset of theta oscillations during the safe cue. Further-more, we show that SOM activation and desynchronization of the BLA is PL-dependent and promotes discrimination of non-threat. Thus, fear discrimination engages PL-dependent coordination of BLA SOM re-sponses to non-threatening stimuli.

Life Sciences & Biomedicine

Neurosciences

Neurosciences & Neurology

Science & Technology

Details

Title: Subtitle: Prelimbic cortex drives discrimination of non-aversion via amygdala somatostatin interneurons
Creators: Joseph M. Stujenske - Cornell University
Pia-Kelsey O'neill - Columbia University
Carolina Fernandes-Henriques - City University of New York
Itzick Nahmoud - Wayne State University
Samantha R. Goldburg - Northwell Health
Ashna Singh - Cornell University
Laritza Diaz - Charles E Schmidt Coll Med, Boca Raton, FL 33431 USA
Margarita Labkovich - Icahn School of Medicine at Mount Sinai
William Hardin - Amazon (United States)
Scott S. Bolkan - Princeton University
Thomas R. Reardon - META Health
Timothy J. Spellman - University of Connecticut
C. Daniel Salzman - Columbia University
Joshua A. Gordon - National Institute of Mental Health
Conor Liston - Cornell University
Ekaterina Likhtik - City University of New York
Resource Type: Journal article
Publication Details: Neuron (Cambridge, Mass.), Vol.110(14), pp.2258-2267.e11
DOI: 10.1016/j.neuron.2022.03.020
PMID: 35397211
PMCID: PMC9308671
NLM abbreviation: Neuron
ISSN: 0896-6273
eISSN: 1097-4199
Publisher: Elsevier
Number of pages: 22
Language: English
Date published: 07/20/2022
Academic Unit: Psychological and Brain Sciences
Record Identifier: 9984944741102771

Metrics

4 Record Views