Journal article
Preliminary Investigation of Cerebral Blood Flow and Amyloid Burden in Veterans With and Without Combat-Related Traumatic Brain Injury
The journal of neuropsychiatry and clinical neurosciences, Vol.28(2), pp.89-96
2016
DOI: 10.1176/appi.neuropsych.15050106
PMID: 26548655
Abstract
This study aimed to examine global and regional cerebral blood flow and amyloid burden in combat veterans with and without traumatic brain injury (TBI). Cerebral blood flow (in milliliters per minute per 100 mL) was measured by quantitative [(15)O]water, and amyloid burden was measured by [(11)C]PIB imaging. Mean global cerebral blood flow was significantly lower in veterans with TBI compared with non-TBI veterans. There were essentially no differences between groups for globally normalized regional cerebral blood flow. Amyloid burden did not differ between TBI and non-TBI veterans. Veterans who have suffered a TBI have significantly lower cerebral blood flow than non-TBI controls but did not manifest increased levels of amyloid, globally or regionally.
Details
- Title: Subtitle
- Preliminary Investigation of Cerebral Blood Flow and Amyloid Burden in Veterans With and Without Combat-Related Traumatic Brain Injury
- Creators
- Laura L Boles Ponto - From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ)Thomas M Brashers-Krug - From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ)Ronald K Pierson - From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ)Yusuf Menda - From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ)Laura Acion - From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ)G Leonard Watkins - From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ)John J Sunderland - From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ)Julie A Koeppel - From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ)Ricardo E Jorge - From the Depts. of Radiology (LLBP, YM, GLW, JJS) and Psychiatry (TMB-K, JAK), Roy J. and Lucille A. Carver College of Medicine, and the Dept. of Biostatistics, College of Public Health (LA), University of Iowa, Iowa City, IA; the Iowa City Veterans Administration Medical Center (TMB-K), Iowa City, IA; Brain Image Analysis, LLC, Iowa City, IA (RKP); the Iowa Consortium for Substance Abuse Research and Evaluation, Iowa City, IA (LA); and the Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX (REJ)
- Resource Type
- Journal article
- Publication Details
- The journal of neuropsychiatry and clinical neurosciences, Vol.28(2), pp.89-96
- DOI
- 10.1176/appi.neuropsych.15050106
- PMID
- 26548655
- NLM abbreviation
- J Neuropsychiatry Clin Neurosci
- ISSN
- 0895-0172
- eISSN
- 1545-7222
- Publisher
- United States
- Language
- English
- Date published
- 2016
- Academic Unit
- Radiology; Psychiatry; Pharmaceutical Sciences and Experimental Therapeutics; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984047692902771
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