Journal article
Preliminary Research on a COVID-19 Test Strategy to Guide Quarantine Interval in University Students
COVID, Vol.2(3), pp.254-260
03/01/2022
DOI: 10.3390/covid2030020
Abstract
Following COVID-19 exposure, the Centers for Disease Control (CDC) recommends a 10-14-day quarantine for asymptomatic individuals and more recently a 7-day quarantine with a negative PCR test. A university-based prospective cohort study to determine if early polymerase chain reaction (PCR) negativity predicts day 14 negativity was performed. A total of 741 asymptomatic students in quarantine was screened and 101 enrolled. Nasopharyngeal swabs were tested on days 3 or 4, 5, 7, 10, and 14, and the proportion of concordant negative results for each day versus day 14 with a two-sided 95% exact binomial confidence interval was determined. Rates of concordant negative test results were as follows: day 5 vs. day 14 = 45/50 (90%, 95% CI: 78-97%); day 7 vs. day 14 = 47/52 (90%, 95% CI: 79-97%); day 10 vs. day 14 = 48/53 (91%, 95% CI:79-97%), with no evidence of different negative rates between earlier days and day 14 by McNemar's test, p > 0.05. Overall, 14 of 90 (16%, 95% CI: 9-25%) tested positive while in quarantine, with seven initial positive tests on day 3 or 4, 5 on day 5, 2 on day 7, and none on day 10 or 14. Based on concordance rates between day 7 and 14, we anticipate that 90% (range: 79-97%) of individuals who are negative on day 7 will remain negative on day 14, providing the first direct evidence that exposed asymptomatic students ages 18-44 years in a university setting are at low risk if released from quarantine at 7 days if they have a negative PCR test prior to release. In addition, the 16% positive rate supports the ongoing need to quarantine close contacts of COVID-19 cases.
Details
- Title: Subtitle
- Preliminary Research on a COVID-19 Test Strategy to Guide Quarantine Interval in University Students
- Creators
- Jill M. Kolesar - University of KentuckyTyler Gayheart - University of KentuckyLance Poston - University of KentuckyEric Monday - University of KentuckyDerek Forster - University of KentuckyElizabeth Belcher - Markey Cancer CenterRani Jaiswal - Markey Cancer CenterJ. Kirsten Turner - University of KentuckyDonna K. Arnett - University of KentuckyEric B. Durbin - Markey Cancer CenterJoseph Monroe - University of KentuckyFrank Romanelli - University of KentuckySusanne M. Arnold - University of KentuckyC. Darrell Jennings - University of KentuckyHeidi Weiss - University of KentuckyRobert DiPaola - University of Kentucky
- Resource Type
- Journal article
- Publication Details
- COVID, Vol.2(3), pp.254-260
- Publisher
- Mdpi
- DOI
- 10.3390/covid2030020
- ISSN
- 2673-8112
- eISSN
- 2673-8112
- Number of pages
- 7
- Grant note
- P30 CA177558 / NCI Cancer Center Support Grant; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Alternative title
- COVID-19 Test Strategy to Guide Quarantine Interval in University Student
- Language
- English
- Date published
- 03/01/2022
- Academic Unit
- Pharmacy; Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984695803702771
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