Logo image
Preliminary Study of the Association of White-Matter Metabolite Concentrations With Disease Severity in Patients With Huntington’s Disease
Journal article   Open access   Peer reviewed

Preliminary Study of the Association of White-Matter Metabolite Concentrations With Disease Severity in Patients With Huntington’s Disease

Jeffrey R Yager, Charles Gasparovic, Vincent A Magnotta, William Adams, Jess Fiedorowicz, Jane Paulsen, Ricardo Jorge and Leigh J Beglinger
The journal of neuropsychiatry and clinical neurosciences, Vol.26(1), pp.101-104
01/2014
DOI: 10.1176/appi.neuropsych.13020040
PMID: 24515683
url
https://www.ncbi.nlm.nih.gov/pmc/articles/7853078View
Open Access

Abstract

Proton magnetic resonance spectroscopy is used to measure several metabolites in cortical gray and white matter in patients with Huntington’s disease. The preliminary results show that CAG-repeat length correlates with white-matter N-acetylaspartate concentrations, and disease severity correlates with several metabolites.

Details

Metrics

Logo image