Preliminary experience in treating skull base chordomas with high-dose hyperfractionated stereotactic photon radiation therapy

Arshin Sheybani; Raheel Ahmed; Mindi TenNapel; Edward C Pennington; Daniel E Hyer; Kathleen M Anderson; Arnold H Menezes; Patrick Hitchon; John M Buatti

doi:10.1007/s13566-013-0122-7

$Preliminary experience in treating skull base chordomas with high-dose hyperfractionated stereotactic photon radiation therapy$

Journal article

Peer reviewed

Preliminary experience in treating skull base chordomas with high-dose hyperfractionated stereotactic photon radiation therapy

Arshin Sheybani, Raheel Ahmed, Mindi TenNapel, Edward C Pennington, Daniel E Hyer, Kathleen M Anderson, Arnold H Menezes, Patrick Hitchon and John M Buatti

Journal of radiation oncology, Vol.3(1), pp.57-64

03/2014

DOI: 10.1007/s13566-013-0122-7

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Abstract

Objective Skull base chordomas (SBC) are characterized by persistent progression. Conventional radiation following resection increases 5- and 10-year local control (LC) to 36 and 23 %, respectively. Patients treated with protons result in 10-year LC of 50 %. Brainstem dose constraints have inhibited higher prescription doses with photons. We reviewed our experience using high-dose fractionated stereotactic photon radiation therapy (HD-FSRT) to 81 Gy for SBC. Methods We reviewed patients diagnosed with SBC and treated with radiation from 1999 to 2010. We excluded those with metastatic disease and prior radiation. Dose distributions and target volumes were obtained from radiation records. Results Twelve patients met the search criteria. Median dose was 81 Gy (76.8–82.5) using a hyperfractionated regimen. Eleven patients with available data had median max and mean doses to the brainstem of 81 Gy (46.7–85.7) and 38 Gy (6.6–58.1). Mean target volume was 22 cm3 (5.3–193. 3). LC at 3 and 5 years was 69 and 46 %. Overall survival was 90 and 68 % with a mean follow-up of 55 months. There was a trend for improved LC in patients treated adjuvantly. Conclusion HD-FSRT can achieve comparable doses to proton therapy plans, and preliminary results are an improvement from conventional photon therapy.

Details

Title: Subtitle: Preliminary experience in treating skull base chordomas with high-dose hyperfractionated stereotactic photon radiation therapy
Creators: Arshin Sheybani
Raheel Ahmed
Mindi TenNapel
Edward C Pennington
Daniel E Hyer
Kathleen M Anderson
Arnold H Menezes
Patrick Hitchon
John M Buatti
Resource Type: Journal article
Publication Details: Journal of radiation oncology, Vol.3(1), pp.57-64
DOI: 10.1007/s13566-013-0122-7
ISSN: 1948-7894
eISSN: 1948-7908
Language: English
Date published: 03/2014
Academic Unit: Neurosurgery; Roy J. Carver Department of Biomedical Engineering; Social Work; Otolaryngology; Radiation Oncology; Stead Family Department of Pediatrics
Record Identifier: 9984040472902771

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