Journal article
Preliminary experimental investigation of in vivo magnetic manipulation: results and potential application in hyperthermia
Medical physics (Lancaster), Vol.16(2), pp.263-272
1989
DOI: 10.1118/1.596421
PMID: 2654597
Abstract
The first in vivo experiments in support of a new technique for delivering stereotaxic hyperthermia have been conducted at the Experimental Surgery Facility of the University of Virginia's Medical Center. We call this technique the “Video Tumor Fighter.” In each of twelve trials a single, small permanent magnet or train of small permanent magnets was implanted on the brain surface of adult canine models. In three of the trials, this “seed” (typically 6-mm diameter ×6-mm long) was moved by magnetic manipulation to different locations within the brain. In two other trials, the seed moved along the interface between the brain and the inner vault of the skull. The noncontact magnetic manipulation was accomplished by coupling the permanently magnetized seed to the large dc magnetic field gradient created by a water-cooled coil surrounding the animal's head. The seed's motions were monitored with x-ray fluoroscopy; its rate of movement was found to be ∼0.8 mm s−1. The forces required to produce these motions were on the order of 0.07 N. We document here the instrumentation used in these trials, describe the experimental procedures employed, and discuss the technical aspects of the results.
Details
- Title: Subtitle
- Preliminary experimental investigation of in vivo magnetic manipulation: results and potential application in hyperthermia
- Creators
- M. S GRADY - Univ. Washington, dep. neurological surgery, Seattle WA 98104, United StatesM. A HOWARD - Univ. Washington, dep. neurological surgery, Seattle WA 98104, United StatesJ. A MOLLOY - Univ. Washington, dep. neurological surgery, Seattle WA 98104, United StatesR. C RITTER - Univ. Washington, dep. neurological surgery, Seattle WA 98104, United StatesE. G QUATE - Univ. Washington, dep. neurological surgery, Seattle WA 98104, United StatesG. T GILLIES - Univ. Washington, dep. neurological surgery, Seattle WA 98104, United States
- Resource Type
- Journal article
- Publication Details
- Medical physics (Lancaster), Vol.16(2), pp.263-272
- Publisher
- American Association of Physicists in Medicine; Melville, NY
- DOI
- 10.1118/1.596421
- PMID
- 2654597
- ISSN
- 0094-2405
- eISSN
- 2473-4209
- Language
- English
- Date published
- 1989
- Academic Unit
- Neurology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984018402302771
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