Journal article
Preliminary results of linear accelerator radiosurgery for acoustic schwannomas
Journal of neurosurgery, Vol.85(6), pp.1013-1019
12/1996
DOI: 10.3171/jns.1996.85.6.1013
PMID: 8929489
Abstract
✓ In this paper the authors evaluate the results of linear accelerator (LINAC)—based stereotactic radiosurgery for acoustic schwannomas. Fifty-six patients underwent LINAC-based stereotactic radiosurgery for acoustic schwannomas at the University of Florida between July 1988 and November 1994. Each patient was followed for a minimum of 1 year or until death; no patient was lost to follow up. One or more follow-up magnetic resonance images or computerized tomography scans were obtained in 52 of the 56 patients. Doses ranged between 10 and 22.5 Gy with 69.6% of patients receiving 12.5 to 15 Gy. Thirty-eight patients (68%) were treated with one isocenter and the dose was specified to the 80% isodose line in 71% of patients. Fifty-five patients (98%) achieved local control after treatment. The 5-year actuarial local control rate was 95%. At the time of analysis, 48 patients were alive and free of disease, seven had died of intercurrent disease, and one was alive with disease. Complications developed in 13 patients (23%). The likelihood of complications was related to the dose and treatment volume: 10 to 12.5 Gy to all volumes, three (13%) of 23 patients; 15 to 17.5 Gy to 5.5 cm3 or less, two (9%) of 23 patients; 15 to 17.5 Gy to more than 5.5 cm3, five (71%) of seven patients; and 20 to 22.5 Gy to all volumes, three (100%) of three patients. Linear accelerator—based stereotactic radiosurgery results in a high rate of local control at 5 years. The risk of complications is related to the dose and treatment volume.
Details
- Title: Subtitle
- Preliminary results of linear accelerator radiosurgery for acoustic schwannomas
- Creators
- William M MendenhallWilliam A FriedmanJohn M BuattiFrancis J Bova
- Resource Type
- Journal article
- Publication Details
- Journal of neurosurgery, Vol.85(6), pp.1013-1019
- DOI
- 10.3171/jns.1996.85.6.1013
- PMID
- 8929489
- ISSN
- 0022-3085
- eISSN
- 1933-0693
- Language
- English
- Date published
- 12/1996
- Academic Unit
- Radiation Oncology; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040597302771
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