Journal article
Premature ventricular contraction-induced cardiomyopathy: Related clinical and electrophysiologic parameters
Heart rhythm, Vol.13(1), pp.103-110
01/2016
DOI: 10.1016/j.hrthm.2015.08.025
PMID: 26296327
Abstract
Factors associated with premature ventricular contraction-induced cardiomyopathy (PVCi-CMP) remain debated.
The purpose of this study was to test the correlation of various factors to the presence PVCi-CMP in a large multicenter population.
One hundred sixty-eight consecutive patients referred for ablation of frequent premature ventricular contractions (PVCs) were included. Patients were divided into 2 groups: group 1 with suspected PVCi-CMP (96 patients, ejection fraction 38% ± 10%, left ventricular end-diastolic diameter 62 ± 8 mm, with or without additional structural heart disease); and group 2 (control group, 72 patients with normal ejection fraction and left ventricular dimensions). Various clinical and electrophysiologic parameters were compared between groups.
In univariate analysis, left ventricular origin of PVC, lack of palpitations, long PVC coupling interval, epicardial origin of the focus, long sinus beat QRS duration, male gender, high PVC burden, presence of polymorphic PVCs, high PVC QRS duration, and older age were significantly related to the presence of PVCi-CMP. In multivariate analysis, only lack of palpitations, PVC burden, and epicardial origin remained significantly and independently correlated with the presence of cardiomyopathy. Even if sinus QRS duration or PVC left ventricular origin were also found independently linked to PVCi-CMP in the whole population, they were no longer correlated when patients with additional heart disease were excluded.
Lack of palpitations, PVC burden, and epicardial origin are independent factors that identify patients prone to developing PVCi-CMP.
Details
- Title: Subtitle
- Premature ventricular contraction-induced cardiomyopathy: Related clinical and electrophysiologic parameters
- Creators
- Marie Sadron Blaye-Felice - University Hospital Rangueil, Toulouse, FranceDavid Hamon - University Hospital Mondor, Paris, FranceFrédéric Sacher - Hôpital Cardiologique du Haut-LévêquePatrizio Pascale - Hôpital Orthopédique de la Suisse RomandeAnne Rollin - Hôpital RangueilAlexandre Duparc - Hôpital RangueilPierre Mondoly - Hôpital RangueilNicolas Derval - Hôpital Cardiologique du Haut-LévêqueArnaud Denis - Hôpital Cardiologique du Haut-LévêqueChristelle Cardin - Hôpital RangueilMélèze Hocini - Hôpital Cardiologique du Haut-LévêquePierre Jaïs - University Hospital Haut-Leveque, Bordeaux-Pessac, FranceJürg Schlaepfer - Hôpital Orthopédique de la Suisse RomandeVanina Bongard - Hôpital RangueilDidier Carrié - Hôpital RangueilMichel Galinier - Hôpital RangueilEtienne Pruvot - Hôpital Orthopédique de la Suisse RomandeNicolas Lellouche - University Hospital Mondor, Paris, FranceMichel Haïssaguerre - University Hospital Haut-Leveque, Bordeaux-Pessac, FrancePhilippe Maury - Hôpital Rangueil
- Resource Type
- Journal article
- Publication Details
- Heart rhythm, Vol.13(1), pp.103-110
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.hrthm.2015.08.025
- PMID
- 26296327
- ISSN
- 1547-5271
- eISSN
- 1556-3871
- Language
- English
- Date published
- 01/2016
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984691516502771
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