Journal article
Prenatal diagnosis of nonsyndromic congenital heart defects
Prenatal diagnosis, Vol.34(3), pp.214-222
03/2014
DOI: 10.1002/pd.4282
PMCID: PMC4482476
PMID: 24222433
Abstract
ABSTRACT
Objectives
Congenital heart defects (CHDs) occur in nearly 1% of live births. We sought to assess factors associated with prenatal CHD diagnosis in the National Birth Defects Prevention Study (NBDPS).
Methods
We analyzed data from mothers with CHD‐affected pregnancies from 1998 to 2005. Prenatal CHD diagnosis was defined as affirmative responses to questions about abnormal prenatal ultrasounds and fetal echocardiography obtained during a structured telephone interview.
Results
Fifteen percent (1097/7299) of women with CHD‐affected pregnancies (excluding recognized syndromes and single‐gene disorders) reported receiving a prenatal CHD diagnosis. Prenatal CHD diagnosis was positively associated with advanced maternal age, family history of CHD, type 1 or type 2 diabetes, twin or higher‐order gestation, CHD complexity, and presence of extracardiac defects. Prenatal CHD diagnosis was inversely associated with maternal Hispanic race/ethnicity, prepregnancy overweight or obesity, and preexisting hypertension. Prenatal CHD diagnosis varied by time to NBDPS interview and NBDPS study site.
Conclusions
Further work is warranted to identify reasons for the observed variability in maternal reports of prenatal CHD diagnosis and the extent to which differences in health literacy or health system factors such as access to specialized prenatal care and fetal echocardiography may account for such variability. © 2013 John Wiley & Sons, Ltd.
What's already known about this topic?
Prenatal diagnosis of congenital heart defects (CHD) can lead to more timely interventions which may improve outcomes
What does this study add?
15% of mothers with a CHD‐affected pregnancy reported receiving a prenatal diagnosis
Prenatal diagnosis varied by infant/fetal characteristics such as CHD type, CHD complexity and presence of extracardiac defects; maternal factors including age, race/ethnicity, family history of CHD, plurality, prepregnancy diabetes, hypertension, and body mass index; and NBDPS study site and time to interview
Details
- Title: Subtitle
- Prenatal diagnosis of nonsyndromic congenital heart defects
- Creators
- Elizabeth C Ailes - CDCSuzanne M Gilboa - CDCTiffany Riehle‐Colarusso - CDCCandice Y Johnson - CDCCharlotte A Hobbs - University of Arkansas for Medical SciencesAdolfo Correa - University of Mississippi Medical CenterMargaret A Honein - CDCNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Prenatal diagnosis, Vol.34(3), pp.214-222
- DOI
- 10.1002/pd.4282
- PMID
- 24222433
- PMCID
- PMC4482476
- ISSN
- 0197-3851
- eISSN
- 1097-0223
- Number of pages
- 9
- Language
- English
- Date published
- 03/2014
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984214802602771
Metrics
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