Journal article
Prenatal diagnosis of orofacial clefts, National Birth Defects Prevention Study, 1998-2004: PRENATAL DIAGNOSIS OF OROFACIAL CLEFTS
Prenatal diagnosis, Vol.29(9), pp.833-839
09/2009
DOI: 10.1002/pd.2293
Abstract
Objective
The aims of this study were to determine how frequently orofacial clefts were diagnosed prenatally and to investigate factors associated with prenatal diagnosis.
Methods
We included 2298 mothers from the National Birth Defects Prevention Study, each of whom gave birth to a child with an orofacial cleft, and assessed associated factors using logistic regression.
Results
The frequencies of prenatal diagnosis for cleft lip and palate, cleft lip only, and cleft palate only were 33.3%, 20.3%, and 0.3%, respectively. Among cases with cleft lip with or without cleft palate, cleft type, geographic location, maternal body mass index, household income, year of infant's birth, and presence of multiple birth defects were significantly associated with receiving a prenatal diagnosis.
Conclusion
In the majority of infants with orofacial clefts, a prenatal diagnosis was not made. Receiving a prenatal diagnosis was significantly associated with several infant and maternal characteristics.
Details
- Title: Subtitle
- Prenatal diagnosis of orofacial clefts, National Birth Defects Prevention Study, 1998-2004: PRENATAL DIAGNOSIS OF OROFACIAL CLEFTS
- Creators
- Candice Y JohnsonMargaret A HoneinCharlotte A HobbsSonja A RasmussenNational Birth Defects Prevention Study
- Contributors
- Paul A Romitti (Contributor) - University of Iowa, Epidemiology
- Resource Type
- Journal article
- Publication Details
- Prenatal diagnosis, Vol.29(9), pp.833-839
- DOI
- 10.1002/pd.2293
- ISSN
- 0197-3851
- eISSN
- 1097-0223
- Language
- English
- Date published
- 09/2009
- Academic Unit
- Biostatistics; Epidemiology
- Record Identifier
- 9984214671402771
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