Journal article
Prenatal nitrate intake from drinking water and selected birth defects in offspring of participants in the national birth defects prevention study
Environmental health perspectives, Vol.121(9), pp.1083-1089
09/2013
DOI: 10.1289/ehp.1206249
PMCID: PMC3764078
PMID: 23771435
Abstract
Previous studies of prenatal exposure to drinking-water nitrate and birth defects in offspring have not accounted for water consumption patterns or potential interaction with nitrosatable drugs.
We examined the relation between prenatal exposure to drinking-water nitrate and selected birth defects, accounting for maternal water consumption patterns and nitrosatable drug exposure.
With data from the National Birth Defects Prevention Study, we linked addresses of 3,300 case mothers and 1,121 control mothers from the Iowa and Texas sites to public water supplies and respective nitrate measurements. We assigned nitrate levels for bottled water from collection of representative samples and standard laboratory testing. Daily nitrate consumption was estimated from self-reported water consumption at home and work.
With the lowest tertile of nitrate intake around conception as the referent group, mothers of babies with spina bifida were 2.0 times more likely (95% CI: 1.3, 3.2) to ingest ≥ 5 mg nitrate daily from drinking water (vs. < 0.91 mg) than control mothers. During 1 month preconception through the first trimester, mothers of limb deficiency, cleft palate, and cleft lip cases were, respectively, 1.8 (95% CI: 1.1, 3.1), 1.9 (95% CI: 1.2, 3.1), and 1.8 (95% CI: 1.1, 3.1) times more likely than control mothers to ingest ≥ 5.42 mg of nitrate daily (vs. < 1.0 mg). Higher water nitrate intake did not increase associations between prenatal nitrosatable drug use and birth defects.
Higher water nitrate intake was associated with several birth defects in offspring, but did not strengthen associations between nitrosatable drugs and birth defects.
Details
- Title: Subtitle
- Prenatal nitrate intake from drinking water and selected birth defects in offspring of participants in the national birth defects prevention study
- Creators
- Jean D Brender - Department of Epidemiology and Biostatistics, School of Rural Public Health, Texas A&M Health Science Center, College Station, Texas 77843, USA. jdbrender@srph.tamhsc.eduPeter J WeyerPaul A RomittiBinayak P MohantyMayura U ShindeAnn M VuongJoseph R SharkeyDipankar DwivediScott A HorelJiji KantamneniJohn C Huber JrQi ZhengMartha M WerlerKatherine E KelleyJohn S GriesenbeckF Benjamin Zhan - Texas State UniversityPeter H LangloisLucina SuarezMark A CanfieldNational Birth Defects Prevention Study
- Resource Type
- Journal article
- Publication Details
- Environmental health perspectives, Vol.121(9), pp.1083-1089
- DOI
- 10.1289/ehp.1206249
- PMID
- 23771435
- PMCID
- PMC3764078
- NLM abbreviation
- Environ Health Perspect
- ISSN
- 0091-6765
- eISSN
- 1552-9924
- Publisher
- United States
- Grant note
- U01 DD000494 / NCBDD CDC HHS P30 ES005605 / NIEHS NIH HHS 3R01ES015634-03S1 / NIEHS NIH HHS R01 ES015634 / NIEHS NIH HHS U01DD000494 / NCBDD CDC HHS 5R01ES015634 / NIEHS NIH HHS
- Language
- English
- Date published
- 09/2013
- Academic Unit
- Occupational and Environmental Health; Epidemiology; Biostatistics
- Record Identifier
- 9983996062002771
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