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Prenatal stress and inhibitory neuron systems: implications for neuropsychiatric disorders
Journal article   Open access   Peer reviewed

Prenatal stress and inhibitory neuron systems: implications for neuropsychiatric disorders

Rebecca Fine, Jie Zhang and Hanna E Stevens
Molecular psychiatry, Vol.19(6), pp.641-651
06/2014
DOI: 10.1038/mp.2014.35
PMCID: PMC4031286
PMID: 24751963
url
https://doi.org/10.1038/mp.2014.35View
Published (Version of record) Open Access

Abstract

Prenatal stress is a risk factor for several psychiatric disorders in which inhibitory neuron pathology is implicated. A growing body of research demonstrates that inhibitory circuitry in the brain is directly and persistently affected by prenatal stress. This review synthesizes research that elucidates how this early, developmental risk factor impacts inhibitory neurons and how these findings intersect with research on risk factors and inhibitory neuron pathophysiology in schizophrenia, anxiety, autism and Tourette syndrome. The specific impact of prenatal stress on inhibitory neurons, particularly developmental mechanisms, may elucidate further the pathophysiology of these disorders.

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