Journal article
Prenatal to Early Postnatal Nicotine Exposure Impairs Central Chemoreception and Modifies Breathing Pattern in Mouse Neonates: A Probable Link to Sudden Infant Death Syndrome
The Journal of neuroscience, Vol.28(51), pp.13907-13917
12/17/2008
DOI: 10.1523/JNEUROSCI.4441-08.2008
PMCID: PMC6671915
PMID: 19091979
Abstract
Nicotine is a neuroteratogen and is the likely link between maternal cigarette smoking during pregnancy and sudden infant death syndrome (SIDS). Osmotic minipumps were implanted in 5-7 d CF1 pregnant mice to deliver nicotine bitartrate (60 mg Kg(-1) day(-1)) or saline (control) solutions for up to 28 d. Prenatal to early postnatal nicotine exposure did not modify the number of newborns per litter or their postnatal growth; however, nicotine-exposed neonates hypoventilated and had reduced responses to hypercarbia (inhalation of air enriched with 10% CO2 for 20 min) and hypoxia (inhalation of 100% N-2 for 20 s) at postnatal days 0-3 (P0-P3). In contrast, at postnatal day 8, nicotine-exposed neonates were indistinguishable from controls. Isolated brainstem-spinal cord preparations obtained from P0 to P3 nicotine-exposed neonates showed fictive respiration with respiratory cycles longer and more irregular than those of controls, as indicated by high short- and long-term variability in Poincare plots. In addition, their responses to acidification were reduced, indicating compromise of central chemoreception. Furthermore, the cholinergic contribution to central chemosensory responses switched from muscarinic receptor to nicotinic receptor-based mechanisms. No significant astrogliosis was detectable in the ventral respiratory group of neurons with glial fibrillary acidic protein immunohistochemistry. These results indicate that nicotine exposure affects the respiratory rhythm pattern generator and causes a decline in central chemoreception during early postnatal life. Consequently, breathing would become highly vulnerable, failing to respond to chemosensory demands. Such impairment could be related to the ventilatory abnormalities observed in SIDS.
Details
- Title: Subtitle
- Prenatal to Early Postnatal Nicotine Exposure Impairs Central Chemoreception and Modifies Breathing Pattern in Mouse Neonates: A Probable Link to Sudden Infant Death Syndrome
- Creators
- Jaime Eugenin - Universidad de Santiago de ChileMarcelo Otarola - Universidad de Santiago de ChileEduardo Bravo - Universidad de Santiago de ChileClaudio Coddou - Universidad de Santiago de ChileVeronica Cerpa - Universidad de Santiago de ChileMiguel Reyes-Parada - Universidad de Santiago de ChileIsabel Llona - Universidad de Santiago de ChileRommy von Bernhardi - Pontificia Universidad Católica de Chile
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.28(51), pp.13907-13917
- Publisher
- Soc Neuroscience
- DOI
- 10.1523/JNEUROSCI.4441-08.2008
- PMID
- 19091979
- PMCID
- PMC6671915
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Number of pages
- 11
- Grant note
- Vicerrectoria de Investigacion y Desarrollo 1060110 / Fondo Nacional de Desarrollo Cientifico y Technologico; Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT); CONICYT FONDECYT Departamento de Investigaciones Cientificas y Technologicas - Universidad de Santiago de Chile (USACH)
- Language
- English
- Date published
- 12/17/2008
- Academic Unit
- Neurology
- Record Identifier
- 9984383907102771
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