Journal article
Preoperative FDG-PET imaging to assess the malignant potential of follicular neoplasms of the thyroid
Otolaryngology--head and neck surgery, Vol.138(1), pp.101-106
2008
DOI: 10.1016/j.otohns.2007.09.008
PMID: 18165002
Abstract
When a fine needle aspiration biopsy of a thyroid nodule suggests follicular neoplasm, surgery is required for diagnosis. Establishing the diagnosis preoperatively would allow the patient to undergo the appropriate initial thyroidectomy. Preoperative [
18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) imaging may be able to determine malignancy in follicular neoplasms.
Prospective cases series.
Twenty-three patients with a diagnosis of follicular neoplasm underwent presurgical FDG-PET at 60, 90, and 120 minutes after injection of fluorodeoxyglucose (F18). Thyroidectomy was performed with comparison of the histopathologic results with the FDG-PET results.
There were 5 malignant conditions and 18 benign conditions identified with the standard uptake valve (SUV) ranging from 0.9 to 44.8. The follicular thyroid cancers that exhibited only capsular invasion had an average SUV of 3.1, whereas those with vascular invasion had an average SUV of 39.9. The SUV increased in 80% of the malignant cases but in only 50% of the benign cases.
Despite certain patterns being suggestive of malignancy, FDG-PET can not consistently predict the malignant potential of a follicular neoplasm.
Details
- Title: Subtitle
- Preoperative FDG-PET imaging to assess the malignant potential of follicular neoplasms of the thyroid
- Creators
- Russell B Smith - Department of Otolaryngology–Head and Neck Surgery, University of Nebraska, Omaha, NERobert A Robinson - Department of Pathology, Roy and Lucille Carver College of Medicine, University of Iowa, Iowa City, IAHenry T Hoffman - Department of Otolaryngology–Head and Neck Surgery, Roy and Lucille Carver College of Medicine, University of Iowa, Iowa City, IAMichael M Graham
- Resource Type
- Journal article
- Publication Details
- Otolaryngology--head and neck surgery, Vol.138(1), pp.101-106
- DOI
- 10.1016/j.otohns.2007.09.008
- PMID
- 18165002
- NLM abbreviation
- Otolaryngol Head Neck Surg
- ISSN
- 0194-5998
- eISSN
- 1097-6817
- Publisher
- Mosby, Inc
- Language
- English
- Date published
- 2008
- Academic Unit
- Radiology; Oral Pathology, Radiology and Medicine; Pathology; Radiation Oncology; Otolaryngology
- Record Identifier
- 9984006421802771
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